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Table 3 Disease incidence and maximum arthritis score in C57BL/6 J mice

From: Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis

Cocktail

B-LPS

A-LPS

Incidence

Max arthritis score (mean ± SEM)

Incidence

Max arthritis score (mean ± SEM)

2 mg Cab4

7/12

1.73 ± 0.38

12/12

9.09 ± 1.68*

2 mg Cab3

0/7

0

6/7

6.00 ± 1.86

2 mg anti-CII

4/11

0.91 ± 0.32

6/11

4.27 ± 1.40*

4 mg Cab4

4/11

1.91 ± 1.35

10/11

12.55 ± 3.36

4 mg Cab3

0/7

0

6/7

8.29 ± 3.32

4 mg anti-CII

3/11

0.73 ± 0.41

8/11

5.82 ± 1.55

  1. Comparisons were done between 2 mg/4 mg Cab4 and 2 mg/4 mg anti-CII or between 2 mg/4 mg Cab3 and 2 mg/4 mg anti-CII in regard to max arthritis score. Significant difference was observed between 2 mg Cab4 and 2 mg anti-CII after LPS injection. Cab4: M2139 ± L10D9 ± 15A11 ± ACC1; Cab3: M2139 ± L10D9 ± 15A11; anti-CII: M2139 ± UL1 ± CIIC1 ± CIIC2. 2 mg Cab4 vs 2 mg anti-CII: *p < 0.05. The one-way ANOVA with Dunn’s multiple comparisons test was used to calculate the level of significance
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Arthritis Research & Therapy

ISSN: 1478-6362

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