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Table 3 Disease incidence and maximum arthritis score in C57BL/6 J mice

From: Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis

Cocktail B-LPS A-LPS
Incidence Max arthritis score (mean ± SEM) Incidence Max arthritis score (mean ± SEM)
2 mg Cab4 7/12 1.73 ± 0.38 12/12 9.09 ± 1.68*
2 mg Cab3 0/7 0 6/7 6.00 ± 1.86
2 mg anti-CII 4/11 0.91 ± 0.32 6/11 4.27 ± 1.40*
4 mg Cab4 4/11 1.91 ± 1.35 10/11 12.55 ± 3.36
4 mg Cab3 0/7 0 6/7 8.29 ± 3.32
4 mg anti-CII 3/11 0.73 ± 0.41 8/11 5.82 ± 1.55
  1. Comparisons were done between 2 mg/4 mg Cab4 and 2 mg/4 mg anti-CII or between 2 mg/4 mg Cab3 and 2 mg/4 mg anti-CII in regard to max arthritis score. Significant difference was observed between 2 mg Cab4 and 2 mg anti-CII after LPS injection. Cab4: M2139 ± L10D9 ± 15A11 ± ACC1; Cab3: M2139 ± L10D9 ± 15A11; anti-CII: M2139 ± UL1 ± CIIC1 ± CIIC2. 2 mg Cab4 vs 2 mg anti-CII: *p < 0.05. The one-way ANOVA with Dunn’s multiple comparisons test was used to calculate the level of significance