Fig. 5

IFN-λ1/3 production by pDCs and pDC-NK cell co-cultures is inhibited by an IRAK4i and HCQ. The levels of IFN-λ1/3 after 20 h in supernatants from healthy donor PDCs and NK cells, stimulated with RNA containing immune complexes (RNA-IC) with or without IRAK4i (10 μM) or HCQ (5.8 μM). Boxplots show medians with interquartile range, based on nine donors in three independent experiments. Friedman’s test. *p < 0.05, **p < 0.01