Table 3 Hazard ratios for reaching remission/low disease activity associated with overlapping SS according to the stratification

 Age

0.74 (0.65, 0.84)^†

0.93 (0.84, 1.04)

0.94 (0.82, 1.07)

0.90 (0.78, 1.03)

0.96 (0.84, 1.10)

0.87 (0.79, 0.97)*

0.94 (0.85, 1.03)

0.92 (0.84, 1.01)

0.91 (0.83, 1.00)

 RF/ACPA

0.68 (0.62, 0.75)^†

0.80 (0.74, 0.87)^†

0.82 (0.74, 0.91)^†

0.77 (0.70, 0.86)^†

0.83 (0.75, 0.92)^†

0.76 (0.70, 0.82)^†

0.80 (0.74, 0.86)^†

0.79 (0.73, 0.85)^†

0.78 (0.73, 0.84)^†

 RA duration

1.45 (0.95, 2.22)

1.45 (0.99, 2.14)

1.18 (0.68, 2.05)

0.88 (0.46, 1.68)

1.13 (0.65, 1.97)

1.44 (1.00, 2.08)

1.48 (1.06, 2.07)

1.39 (0.99, 1.95)

1.40 (1.00, 1.96)

  Duration ≥ 6 months

0.67 (0.61, 0.74)^†

0.80 (0.74, 0.87)^†

0.82 (0.74, 0.91)^†

0.77 (0.70, 0.86)^†

0.83 (0.75, 0.92)^†

0.76 (0.70, 0.82)^†

0.80 (0.74, 0.86)^†

0.79 (0.73, 0.85)^†

0.78 (0.73, 0.84)^†

 DAS28-CRP at 1st visit

0.64 (0.58, 0.70)^†

0.76 (0.70, 0.82)^†

0.76 (0.69, 0.84)^†

0.71 (0.64, 0.79)^†

0.77 (0.70, 0.85)^†

0.73 (0.67, 0.79)^†

0.78 (0.72, 0.84)^†

0.77 (0.71, 0.82)^†

0.76 (0.71, 0.82)^†

 Age

0.81 (0.67, 0.98)*

0.85 (0.73, 0.99)*

0.91 (0.74, 1.11)

0.91 (0.74, 1.13)

0.91 (0.74, 1.11)

0.86 (0.73, 1.00)

0.86 (0.75, 0.99)*

0.82 (0.71, 0.95)*

0.83 (0.72, 0.95)*

 RF/ACPA

0.71 (0.62, 0.82)^†

0.74 (0.66, 0.83)^†

0.82 (0.70, 0.94)*

0.78 (0.67, 0.91)^†

0.80 (0.69, 0.93)^†

0.73 (0.65, 0.82)^†

0.76 (0.68, 0.84)^†

0.74 (0.66, 0.82)^†

0.74 (0.66, 0.82)^†

 RA duration

2.51 (1.36, 4.61)^†

1.93 (1.15, 3.26)*

1.74 (0.81, 3.73)

1.18 (0.51, 2.73)

1.46 (0.70, 3.04)

2.07 (1.26, 3.40)^†

1.77 (1.14, 2.74)*

1.61 (1.04, 2.47)*

1.64 (1.06, 2.53)*

  Duration ≥ 6 months

0.70 (0.61, 0.81)^†

0.74 (0.66, 0.83)^†

0.82 (0.71, 0.95)*

0.78 (0.67, 0.92)^†

0.81 (0.69, 0.94)*

0.73 (0.65, 0.82)^†

0.76 (0.68, 0.84)^†

0.74 (0.66, 0.82)^†

0.74 (0.66, 0.82)^†

 DAS28-CRP at 1st visit

0.70 (0.61, 0.81)^†

0.73 (0.65, 0.82)^†

0.78 (0.67, 0.90)^†

0.75 (0.64, 0.87)^†

0.77 (0.66, 0.89)^†

0.71 (0.64, 0.80)^†

0.73 (0.65, 0.81)^†

0.71 (0.64, 0.79)^†

0.71 (0.64, 0.79)^†

 Age

0.80 (0.66, 0.98)*

0.81 (0.69, 0.95)*

0.90 (0.73, 1.11)

0.87 (0.70, 1.08)

0.90 (0.73, 1.11)

0.83 (0.71, 0.98)*

0.83 (0.72, 0.97)*

0.80 (0.69, 0.93)^†

0.81 (0.70, 0.94)^†

 RF/ACPA

0.74 (0.64, 0.85)^†

0.74 (0.66, 0.83)^†

0.83 (0.72, 0.97)*

0.78 (0.67, 0.91)^†

0.82 (0.70, 0.95)*

0.74 (0.66, 0.83)^†

0.75 (0.68, 0.84)^†

0.74 (0.66, 0.82)^†

0.74 (0.66, 0.82)*

 RA duration

2.49 (1.35, 4.59)^†

1.91 (1.13, 3.22)*

1.72 (0.80, 3.70)

1.16 (0.50, 2.70)

1.45 (0.69, 3.01)

2.05 (1.25, 3.37)*

1.85 (1.19, 2.87)*

1.68 (1.08, 2.59)*

1.71 (1.10, 2.65)^†

  Duration ≥ 6 months

0.72 (0.63, 0.83)^†

0.74 (0.65, 0.83)^†

0.83 (0.72, 0.97)*

0.79 (0.67, 0.92)^†

0.82 (0.71, 0.96)*

0.74 (0.66, 0.83)^†

0.75 (0.68, 0.84)^†

0.73 (0.66, 0.82)^†

0.73 (0.66, 0.82)^†

 DAS28-CRP at 1st visit

0.71 (0.62, 0.82)^†

0.72 (0.64, 0.81)^†

0.79 (0.68, 0.91)^†

0.74 (0.63, 0.86)^†

0.77 (0.66, 0.90)^†

0.71 (0.64, 0.80)^†

0.72 (0.65, 0.80)^†

0.71 (0.64, 0.79)^†

0.71 (0.64, 0.79)^†