Table 2 Significant extracted KEGG 2019 pathways that are associated with p < 0.05, FC > 1.5 or < 0.67 proteins in affected versus unaffected comparison
Pathway | Pathway’s p value | Pathway | Pathway’s p value |
|---|---|---|---|
Hypertrophic cardiomyopathy (HCM) | 1.53E−08 | Staphylococcus aureus infection | 2.25E−02 |
Dilated cardiomyopathy (DCM) | 2.47E−08 | Adherens junction | 2.50E−02 |
Cardiac muscle contraction | 2.61E−07 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 2.50E−02 |
Adrenergic signalling in cardiomyocytes | 6.10E−07 | Kaposi sarcoma-associated herpesvirus infection | 2.55E−02 |
Focal adhesion | 5.90E−05 | Calcium signalling pathway | 2.62E−02 |
Regulation of actin cytoskeleton | 8.81E−05 | Bacterial invasion of epithelial cells | 2.63E−02 |
Pertussis | 1.30E−04 | Gastric acid secretion | 2.70E−02 |
Complement and coagulation cascades | 1.52E−04 | Antigen processing and presentation | 2.83E−02 |
Proteoglycans in cancer | 6.09E−04 | Epstein-Barr virus infection | 3.11E−02 |
Glycolysis/gluconeogenesis | 1.61E−03 | PI3K-Akt signalling pathway | 3.24E−02 |
Phagosome | 1.79E−03 | Human immunodeficiency virus 1 infection | 3.56E−02 |
Cellular senescence | 2.16E−03 | Fc gamma R-mediated phagocytosis | 3.84E−02 |
cGMP-PKG signalling pathway | 2.47E−03 | Small cell lung cancer | 4.00E−02 |
ECM-receptor interaction | 2.75E−03 | Amoebiasis | 4.23E−02;3.79E−02 |
Histidine metabolism | 2.75E−03 | Aldosterone synthesis and secretion | 4.39E−02 |
AGE-RAGE signalling pathway in diabetic complications | 4.80E−03 | Pancreatic secretion | 4.39E−02 |
Human papillomavirus infection | 5.29E−03 | HIF-1 signalling pathway | 4.56E−02 |
Fructose and mannose metabolism | 5.62E−03 | Chagas disease (American trypanosomiasis) | 4.80E−02 |
Leukocyte transendothelial migration | 6.58E−03 | Ribosome | 1.72E−15 |
Human T cell leukaemia virus 1 infection | 6.59E−03 | Huntington disease | 3.82E−04 |
Ferroptosis | 8.17E−03 | Systemic lupus erythematosus | 8.72E−04 |
Platelet activation | 8.70E−03 | Spliceosome | 8.97E−04 |
Carbohydrate digestion and absorption | 9.83E−03 | Synaptic vesicle cycle | 2.00E−03 |
Vascular smooth muscle contraction | 1.03E−02 | Alcoholism | 2.65E−03 |
Apelin signalling pathway | 1.14E−02 | Oxidative phosphorylation | 8.91E−03 |
Parkinson disease | 1.25E−02;1.06E−02 | Endocrine and other factor-regulated calcium reabsorption | 1.03E−02 |
Mineral absorption | 1.30E−02 | Necroptosis | 1.52E−02 |
Cell adhesion molecules (CAMs) | 1.33E−02 | Steroid hormone biosynthesis | 1.58E−02 |
Viral myocarditis | 1.72E−02 | Arachidonic acid metabolism | 1.74E−02 |
Tight junction | 2.02E−02 | Viral carcinogenesis | 2.66E−02 |
Shigellosis | 2.06E−02 |