Fig. 6
From: Targeting a cysteine protease from a pathobiont alleviates experimental arthritis
Impact of the pre-treatments on mediators of inflammation and bone erosion. a Effects of pre-immunization with RgpA domains on mRNA expression levels of inflammatory markers in joint tissue of CIA rats. Real-time PCR was used to quantify expression of MMP9, CXCL1, TNF-alpha, IL-1b, and IL-17 in the ankle synovial tissues of rats. Expression levels were quantified by densitometric analysis of bands and normalized to those of GAPDH mRNA. Data are recorded as mean ± standard deviation from six animals per group. Results are presented as mean ± SEM. *p < 0.05; **p < 0.01; and ***p < 0.001. b Effects of pre-immunization with RgpA domains on serum levels of inflammatory markers in CIA rats. Levels of MMP9, CXCL1, TNF-alpha, IL-1b, and IL-17 were assessed in the sera of the different groups. Results are presented as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001