Table 2 Diagnostic performance of urinary ALCAM and conventional biomarkers in discriminating proliferative LN from membranous LN
From: Urinary activated leukocyte cell adhesion molecule as a novel biomarker of lupus nephritis histology
| Â | Cutoff | AUC | 95% CI | SEN (%) | SPE (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|
ALCAM (ng/mg) | > 12 | 0.81 | 0.70–0.92 | 78.4 | 81.0 | 93.5 | 51.5 |
dsDNA (IU/mL) | > 16.5 | 0.58 | 0.42–0.75 | 74.5 | 50.0 | 79.5 | 42.9 |
C3 (g/L) | < 0.73 | 0.77 | 0.65–0.89 | 75.0 | 73.7 | 91.5 | 43.8 |
C4 (g/L) | < 0.16 | 0.58 | 0.43–0.72 | 79.7 | 36.8 | 82.1 | 33.3 |
24 h UP (g/24 h) | > 2.8 | 0.59 | 0.45–0.73 | 59.7 | 61.9 | 84.3 | 31.0 |