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Table 2 Diagnostic performance of urinary ALCAM and conventional biomarkers in discriminating proliferative LN from membranous LN

From: Urinary activated leukocyte cell adhesion molecule as a novel biomarker of lupus nephritis histology

 CutoffAUC95% CISEN (%)SPE (%)PPV (%)NPV (%)
ALCAM (ng/mg)> 120.810.70–0.9278.481.093.551.5
dsDNA (IU/mL)> 16.50.580.42–0.7574.550.079.542.9
C3 (g/L)< 0.730.770.65–0.8975.073.791.543.8
C4 (g/L)< 0.160.580.43–0.7279.736.882.133.3
24 h UP (g/24 h)> 2.80.590.45–0.7359.761.984.331.0
  1. AUC area under the curve, CI confidence interval, SEN sensitivity, SPE specificity, PPV positive predictive value, NPV negative predictive value, 24-h UP 24-h urine protein