Skip to main content

Table 4 Sensitivity analysis: factors associated with pure proliferative LN

From: Non-histologic factors discriminating proliferative lupus nephritis from membranous lupus nephritis

 

Univariable analysis

Multivariable analysis (model 1)

Multivariable analysis (model 2)

 

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

Age

0.985 (0.954–1.017)

0.351

    

Female sex

1.400 (0.281–6.976)

0.681

    

Hypertension

1.043 (0.318–3.422)

0.945

    

Diabetes mellitus

N/A

0.999

    

Mucocutaneous manifestations

1.046 (0.347–3.153)

0.936

    

Musculoskeletal manifestations

1.932 (0.526–7.097)

0.321

    

Neuropsychiatric manifestations

0.304 (0.071–1.305)

0.109

    

Serositis

3.535 (0.446–28.035)

0.232

    

Hematologic manifestations

4.531 (1.248–16.453)

0.022

4.997 (0.819–30.479)

0.081

2.150 (0.408–11.333)

0.367

Positive anti-Sm Ab

0.718 (0.267–1.936)

0.513

    

Positive anti-Ro Ab

1.051(0.381–2.904)

0.923

    

Positive anti-La Ab

2.262 (0.618–8.279)

0.218

    

Positive anti-U1RNP Aba

0.268 (0.083–0.859)

0.027

0.178 (0.034–0.922)

0.040

0.987 (0.978–0.996)

0.007

Positive anti-dsDNA Aba

8.385 (2.824–24.896)

< 0.001

19.591 (2.518–152.431)

0.004

1.008 (1.002–1.015)

0.012

Positive lupus anticoagulant

1.224 (0.328–4.572)

0.763

    

Positive anti-β2 glycoprotein I Ab

0.337 (0.104–1.088)

0.069

    

Positive anti-cardiolipin Ab

1.854 (0.504–6.819)

0.353

    

Low C3a

14.891 (4.044–54.831)

< 0.001

2.216 (0.216–22.738)

0.503

1.004 (0.959–1.052)

0.866

Low C4a

5.421 (1.906–15.422)

0.002

1.763 (0.313–9.916)

0.520

0.947 (0.839–1.069)

0.376

Albumin level

0.898 (0.420–1.918)

0.781

    

Creatinine level

11.857 (1.524–92.273)

0.018

    

GFR

0.978 (0.961–0.995)

0.012

0.966 (0.941–0.992)

0.010

0.967 (0.942–0.992)

0.011

Urine PCR

0.999 (0.986–1.013)

0.934

    

Urine RBC of ≥ 5/HPF

4.238 (1.515–11.852)

0.006

1.803 (0.358–9.087)

0.475

1.724 (0.299–9.952)

0.542

Urine WBC of ≥ 5/HPF

2.604 (0.917–7.391)

0.072

    

Urine cast

4.381 (0.556–34.519)

0.161

    

SLEDAI-2K

1.181 (1.067–1.308)

0.001

1.026 (0.884–1.190)

0.739

1.094 (0.899–1.330)

0.370

  1. Ab antibody, anti-dsDNA anti-double-stranded DNA, GFR glomerular filtration rate, PCR protein/creatinine ratio, RBC red blood cell, HPF high power field, WBC white blood cell, SLEDAI-2K Systemic Lupus Erythematosus Disease Activity Index 2000, OR odds ratio, CI confidence interval, N/A, not applicable
  2. aAnalyzed as binary variables (anti-U1RNP Ab, positive/negative; anti-dsDNA Ab, positive/negative; C3, low/not low; C4, low/not low) in univariable analysis and multivariable analysis (model 1) and analyzed as continuous variables in multivariable analysis (model 2)
Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us