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Table 4 Cox regression analysis

From: Influence of age on the occurrence of adverse events in rheumatic patients at the onset of biological treatment: data from the BIOBADASER III register

VariablesHazard ratio (CI95%)p
Age (ref. adults)
 Young0.92 (0.60–1.40)0.692
 Elderly1.21 (0.97–1.52)0.089
 Very Elderly1.50 (1.01–2.24)0.046
Female gender1.42 (1.22–1.64)< 0.001
Diagnosis (ref. RA)
 AS0.93 (0.76–1.12)0.432
 PsA0.96 (0.81–1.14)0.668
Comorbidities
 Charlson index1.13 (1.06–1.21)< 0.001
 Smoking (ref. No)
  Smoker/past smoker1.16 (0.99–1.35)0.059
Treatments
 Corticosteroids1.04 (0.85–1.27)0.699
 Corticosteroid dose0.99 (0.97–1.00)0.140
 MTX1.21 (1.05–1.39)0.008
 Other DMARDs1.10 (0.95–1.28)0.182
Disease duration1.01 (1.00–1.02)0.007
  1. AS ankylosing spondylitis, CI95% confidence interval 95%, DMARDs disease-modifying antirheumatic drugs, HR hazard ratios, MTX Methotrexate, PsA psoriatic arthritis, RA rheumatoid arthritis