Table 3 Baseline biomarker concentrations and MBDA scores for patients in LDAS and remission at baseline
From: A multi-biomarker disease activity score can predict sustained remission in rheumatoid arthritis
Baseline Biomarkers | LDAS (n = 40) | DAS28-ESR remission (n = 96) | DAS28-CRP remission (n = 74) | CDAI remission (n = 63) | SDAI remission (n = 59) | ACR/EULAR Boolean remission (n = 37) |
|---|---|---|---|---|---|---|
EGF (pg/ml) | 245 (160, 331) | 254 (177, 368) | 249 (160, 366) | 248 (158, 359) | 243 (157, 362) | 249 (180, 373) |
IL-6 (pg/ml) | 13.65 (9.89, 24.35) | 7.14 (5.56, 13.21)**** | 8.09 (5.67, 12.62)**** | 7.89 (5.58, 13.21)**** | 6.97 (5.41, 11.79)**** | 6.29 (4.41, 9.33)**** |
Leptin (ng/ml) | 25 (6.3, 38) | 8 (4, 17)* | 8 (4, 16) * | 7.00 (3.54, 14.10)* | 6.33 (3.50,13.87)*** | 6.33 (3.50, 11.74)** |
MMP-1 (ng/ml) | 6.62 (4.41, 10.48) | 6.80 (4.93, 9.49) | 7.30 (5.07, 10.63) | 7.52 (5.13, 10.78) | 7.57 (5.19, 10.93) | 7.47 (5.25, 1.09) |
MMP-3 (ng/ml) | 26 (17, 40) | 26 (20, 38) | 26 (17, 35) | 26 (17, 37) | 27 (17, 35) | 27 (17, 40) |
Resistin (ng/ml) | 8.72 (6.40, 12.01) | 7.04 (5.78, 8.72)** | 7.11 (5.84, 9.54)* | 7.37 (6.20, 9.69) | 7.32 (6.04, 9.85) | 7.92 (6.04, 9.54) |
SAA (μl/ml) | 2.82 (1.63, 6.17) | 1.32 (0.69, 2.49)*** | 1.22 (0.65, 2.13)**** | 1.52 (0.65, 2.13)*** | 1.20 (6.43, 2.06)**** | 1.20 (0.65, 2.03)**** |
TNFR1 (ng/ml) | 1.76 (1.37, 2.16) | 1.50 (1.32, 1.92)* | 1.51 (1.35, 1.99) | 1.52 (1.33, 2.01) | 1.51 (1.31, 1.99) | 1.64 (1.34, 1.99) |
VCAM1 (ng/ml) | 587 (469, 732) | 518 (433, 587)** | 519 (440, 588)* | 520 (425, 609)* | 521 (430, 621)* | 531 (457, 621) |
VEGF (pg/ml) | 294 (211, 365) | 240 (166, 374) | 246 (173, 408) | 258 (174, 407) | 247 (173, 407) | 275 (176, 407) |
YKL40 (ng/ml) | 65 (42, 97) | 51 (34, 70)* | 56 (36, 92)* | 53 (35, 102) | 52 (34, 98) | 56 (35, 92) |
CRP (mg/ml) | 6.41 (3.23, 14.10) | 1.49 (0.61, 2.83)**** | 1.57 (0.61, 2.70)**** | 1.40 (0.78, 2.63)**** | 1.40 (0.56, 2.49)**** | 1.40 (0.44, 2.49)**** |
MBDA score (1–100) | 39 (31, 50) | 26 (16, 37)**** | 26 (16, 35)**** | 24 (16, 35)**** | 22 (16, 33)**** | 20 (15, 32)**** |