Fig. 1

Distribution of OSMRβ in human skin biopsies from healthy controls and SSc patients. a IHC staining of OSMRβ was performed on paraffin sections from the skin of healthy controls and SSc patients. b The bar graph represents the staining intensity in endothelial/perivascular cells and fibroblasts (0, no staining; 1, negative or weak staining; 2, moderate staining; and 3, strong staining). Two hundred micrometers for original magnification × 4 and 25 μm for original magnification × 40 images. Results are shown as mean ± SD (Mann-Whitney U test, *p < 0.05, **< 0.01). c Double IF staining of CD31 and OSMRβ in two representative SSc skin biopsies (n = 3 SSc and 3 HC samples). d Double IF staining of αSMA and OSMRβ in two representative SSc skin biopsies. Scale bar 15 μm for original magnification × 60