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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis

Fig. 3

OSM and IL-6+sIL-6R stimulate transition to mesenchymal phenotype in HDMECs. a mRNA levels of EndMT genes were analyzed by quantitative PCR, n = 3. Student’s t test *p < 0.05, **p < 001, ***p < 0.0001. b Immunofluorescence staining of VE-cadherin (green) and phalloidin (red) in the HDMECs culture treated with OSM and IL-6+sIL-6R. Representative images are shown from 3 cell lines. c Representative western blot of VE-cadherin, CD31, αSMA, and TGFβ123 in HDMECs treated with OSM and IL-6+IL-6R for 24 and 48 h. N = 2

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