Skip to main content

Table 1 Characteristics of Vietnamese Kinh people with cutaneous adverse reactions (MCARs), rare severe CARs (SCARs), and controls (no reaction to allopurinol)

From: Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study

  SCARs (n = 31) MCARs (n = 74) Controls (n = 395) P value
Demographic features
 Age, years, mean (SD) 60.0 (15.9) 45.7 (11.7) 45.4 (10.3) < 0.0001
  ≤ 40 2 (6.9) 29 (39.2) 135 (34.2)
  40–65 16 (55.2) 42 (56.8) 249 (63.0)
  > 65 11 (37.9) 3 (4.0) 11 (2.8)
 Female, n (%) 9 (29.0) 0 0 < 0.0001
History of allopurinol-induced skin reaction, n (%) 2/27 (7.4) 2 (2.7) 0 0.003
Indication for allopurinol,n(%)
 Gout 14 (45.2) 72 (97.3) 395 (100) < 0.0001
 Asymptomatic hyperuricemia 17 (54.8) 2 (2.7) 0 < 0.0001
Allopurinol intake
 Daily dose at reaction onset, mg, mean (SD) 303.4 (97.22) 243.2 (110.2) 369.1 (103.8) < 0.0001
 Daily starting dose, mg/day, mean (SD) 303.2 (84.6) 156.1 (29.8) 152.7 (19.8) <0.0001
 Daily starting dose > 150 mg, n (%) 27 (87.1) 3 (4.1) 7 (1.8)
Concomitant diuretics intake,n(%) 7/26 (26.9) 1 (1.4) 0 < 0.0001
Comorbidities,n(%)
 Hypertension 8/15 (53.3) 4 (5.4) 99 (25.1) < 0.0001
 Type 2 diabetes 6/15 (40.0) 3 (4.1) 24 (6.1) 0.0003
 Coronary heart disease 1/15 (6.7) 0 9 (2.3) 0.16
 Dyslipidemia 6/13 (46.2) 6 (8.1) 69 (17.5) 0.003
 eGFR < 60 ml/min/1.73 m2 12/18 (66.7) 6 (8.1) 7 (1.8)  
HLA typing,n(%)
 HLA-B*58:01-positive 29 (93.5) 6 (8.1) 29 (7.3)  
 HLA-B*58:01 homozygote 7/27 (25.9) 1 (16.4) 7 (24.1)  
  1. eGFR estimated glomerular filtration rate