Fig. 1
The TPH enrichment in the synovial membrane of RA patients at baseline therapy is associated with the clinical response. a PD-1hiCXCR5-CD4+ cell enrichment levels at baseline estimated using the cell-type deconvolution approach in our patient cohort. The estimated enrichment scores for TPH cells are significantly associated with the EULAR response at week 20 (P = 0.021). b PD-1hiCXCR5-CD4+ cell percentage at baseline quantified using immunofluorescence in our patient cohort. As seen in the cell-type deconvolution approach, lower TPH cells are associated with better responses to anti-TNF agents (P = 0.025). In both cases, moderate and good EULAR responders show distinctively lower proportions of this pathogenic T cell subset associated with RA