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Table 1 Function and targets of miR-140 in OA

From: Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment

miRNAs Targets Cell type/tissue Function of miR-140 References
miR-140-3p CXCR4 Chondrocytes Ameliorates OA progression [35]
RALA MSCs Promotes chondrogenesis [36]
miR-140-5p IGFBP-5 OA chondrocytes Inhibits OA progression [37]
BMP-2 Bone Impairs embryonic bone development [38]
DNPEP Bone Promotes endochondral bone development [32]
IL-1β; IL-6; Syndecan-4 Chondrocytes Inhibits mediators of inflammation and cartilage degradation and upregulates chondrogenic proteins [39]
TGFBR1 Stromal cell ST2 and preadipocyte 3 T3-L1 Promotes adipocyte differentiation and inhibits osteoblast differentiation from marrow stromal cells [40]
ADAMTS5 Chondrocytes Inhibits ADAMTS5 [33]
MMP-13 Chondrocytes Inhibits IL-1β-induced MMP-13 [41]
SMAD3 Mandibular condylar chondrocytes (MCCs) Inhibits IL-1β-induced inflammation in MCCs [42]
HMGB1 Human chondrocytes C28/I2 Inhibits IL-1β induced OA cell model [43]
TLR4; BMP2 Adipose-derived MSCs Inhibits osteogenesis [44]
RALA MSCs Promotes chondrogenesis [36]
FUT1 Chondrocytes Inhibits apoptosis and promotes proliferation and autophagy of human primary chondrocytes [45]
HDAC4 Chondrocytes Inhibits chondrocyte hypertrophy [46]
SMAD1 Chondrocytes Inhibits chondrocyte hypertrophy [47]