Fig. 4

SLC7A5 impact on the production of cytokines and chemokines in RA FLS. a Images of cytokine array membranes incubated with supernatants from RA FLS, transfected with NC or SLC7A5 siRNA (si-2). The cells were transfected with either negative control or SLC7A5 siRNA (si-2) for 48 h. All the cytokine and chemokine fold change is shown in the heat map. b Semi-quantitative data showing altered cytokine expression (fold change beyond ± 1.5) in RA FLS supernatants 48 h post-siRNA transfection. c KEGG pathway analysis of the differentially expressed cytokines and chemokines in RA FLS