Table 3 Changes in serum adipokines during the study
M0 (N = 107) | M1 (N = 106) | M3 (N = 104) | M6 (N = 97) | M12 (N = 77) | P*, M0 vs M6 (N = 97) | P*, M0 vs M12 (N = 77) | P# | |
|---|---|---|---|---|---|---|---|---|
Total adiponectin (μg/mL) | 14.54 ± 8.1 | 15.5 ± 8.7 | 15.7 ± 9.9 | 14.6 ± 7.5 | 14.2 ± 7.6 | 0.055 | 0.25 | 0.3 |
Total adiponectin (μg/mL), TCZ alone | 15.18 ± 7.8 | 14.75 ± 7.9 | 14.76 ± 6.6 | 15.03 ± 7.5 | 14.23 ± 6.6 | 0.34 | 0.8 | 0.31 |
Total Adiponectin (μg/mL), TCZ and csDMARDs | 14.40 ± 8.3 | 15.82 ± 9.1 | 16.04 ± 11.0 | 14.47 ± 7.6 | 14.14 ± 8.2 | 0.1 | 0.24 | 0.019 |
HMW adiponectin (μg/mL) | 7.3 ± 5.4 | 8.3 ± 6.6 | 8 ± 6.4 | 7.5 ± 5,4 | 6.8 ± 4.6 | 0.011 | 0.057 | 0.01 |
HMW adiponectin (μg/mL), TCZ alone | 7.32 ± 4.50 | 7.87 ± 5.40 | 7.94 ± 5.22 | 7.97 ± 5.21 | 7.03 ± 4.72 | 0.052 | 0.046 | 0.09 |
HMW adiponectin (μg/mL), TCZ and csDMARDs | 7.07 ± 5.28 | 8.42 ± 7.08 | 8.06 ± 6.84 | 7.32 ± 5.47 | 6.73 ± 4.66 | 0.045 | 0.3 | 0.045 |
Leptin (ng/mL) | 32.64 ± 26.9 | 32.45 ± 25.4 | 31.7 ± 23.6 | 32.6 ± 27.3 | 32.8 ± 27.5 | 0.059 | 0.17 | 0.22 |
Leptin/fat mass | 1.08 ± 0.7 | ND | ND | 1.1 ± 0.8 | 1.2 ± 1.4 | 0.049 | 0.2 | 0.14 |
Resistin (ng/mL) | 10.5 ± 4.9 | 11 ± 4.9 | 10.9 ± 4.6 | 10.8 ± 4,9 | 10.9 ± 5.3 | 0.53 | 0.16 | 0.13 |
Ghrelin (pg/mL) | 2121.9 ± 1309.4 | 2031.5 ± 1266 | 2072.9 ± 1299 | 2074.8 ± 1278.4 | 2035 ± 1304.3 | 0.78 | 0.19 | 0.28 |