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Table 3 Direct and indirect effects of E-DII on incident ROA and SxOA for mediation via BMI

From: Inflammatory potential of diet and risk of incident knee osteoarthritis: a prospective cohort study

E-DII < 2.50 ≥ 2.50
ROA n = 894 persons n = 892 persons
 Total effect* 1.00 (ref) 1.47 (1.10, 1.97)
 Direct effect 1.00 (ref) 1.36 (1.02, 1.82)
 Indirect effect via BMI 1.00 (ref) 1.08 (1.04, 1.13)
 Proportion of mediation via BMI 20.4%
SxOA n = 1471 persons n = 1469 persons
 Total effect* 1.00 (ref) 1.31 (1.13, 1.51)
 Direct effect 1.00 (ref) 1.16 (1.01, 1.34)
 Indirect effect via BMI 1.00 (ref) 1.13 (1.09, 1.16)
 Proportion of mediation via BMI 44.5%
  1. E-DII energy-adjusted dietary inflammatory index, BMI body mass index, ROA radiographic knee osteoarthritis, SxOA symptomatic knee osteoarthritis
  2. *Model adjusted for age (years), sex (men vs women), race (white vs non-white), total energy intake (kcal/day), education (< college vs ≥ college), yearly income level (< 50,000 US$ vs ≥ 50,000 US$), tobacco use (non-smoker vs smoker), and physical activity (PASE, continuous)
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