Tocilizumab may slow radiographic progression in patients with systemic or polyarticular-course juvenile idiopathic arthritis: post hoc radiographic analysis from two randomized controlled trials

Table 2 Change from baseline in adapted SH and Poznanski scores

Score	Baseline		Change from baseline to week 52			Change from baseline to week 104
Score	n	Median (IQR)	n	Median (IQR)	P	n	Median (IQR)	P
sJIA
Adapted total SH	47	24.60 (8.50, 39.50)	45	0.00 (− 8.70, 4.00)	0.302	37	0.50 (− 7.50, 12.00)	0.695
Erosion	47	8.50 (1.50, 23.50)	45	0.50 (− 3.50, 1.50)	0.677	37	0.50 (− 1.00, 4.50)	0.257
JSN	47	13.00 (6.00, 19.50)	45	0.00 (− 4.00, 3.00)	0.257	37	0.00 (− 5.50, 4.00)	0.937
Poznanski	33	− 2.38 (− 3.48, − 0.84)	32	0.29 (− 0.05, 1.05)	0.003	26	0.16 (− 0.01, 1.04)	0.057
pcJIA
Adapted total SH	45	8.00 (3.00, 18.50)	40	0.50 (− 7.25, 4.50)	0.700	35	− 1.00 (− 6.50, 2.50)	0.109
Erosion	45	3.00 (0.00, 6.50)	40	0.00 (− 1.50, 1.50)	0.819	36	0.00 (− 2.75, 0.75)	0.402
JSN	45	5.00 (1.00, 14.50)	40	0.25 (− 5.25, 3.50)	0.614	35	− 1.00 (− 3.50, 1.50)	0.109
Poznanski	35	− 1.45 (− 2.51, − 0.75)	31	0.26 (− 0.34, 0.91)	0.077	25	0.55 (0.04, 0.92)	0.004

Abbreviations: IQR interquartile range, JSN joint space narrowing, pcJIA polyarticular-course juvenile idiopathic arthritis, SH Sharp–van der Heijde, sJIA systemic juvenile idiopathic arthritis
SH score: higher score indicates greater damage. Poznanski score: the more negative a Poznanski score, the more severe the radiographic damage

ISSN: 1478-6362