Fig. 1
From: PRMT5 inhibition attenuates cartilage degradation by reducing MAPK and NF-κB signaling
Overexpression of PRMT5 in human osteoarthritis (OA) cartilage. a Hematoxylin and eosin staining and representative immunohistochemical staining for PRMT5 in human cartilage in the control and OA groups. Scale bar = 100 μm. b Increase in the numbers of PRMT5-positive cells in human OA cartilage vs. control cartilage. Results are presented as percentages. c Representative western blots show increases in the expression levels of PRMT5, p-p65, and p-p38 in OA tissues; levels of p65, p38, and GAPDH were identical to those in the control group. d Histogram showing the relative protein expression levels of PRMT5, p-p65, and p-p38 in cartilage tissue. Data are presented as mean ± SD from 3 samples for each group in 3 independent experiments. Data were analyzed using Student’s t test. *P < 0.05 vs. the normal group