Fig. 5
From: PRMT5 inhibition attenuates cartilage degradation by reducing MAPK and NF-κB signaling
EPZ inhibits DMM-induced subchondral bone loss in mouse tibia. a Three-dimensional images of the knee joints in each group, reconstructed using the built-in μCT software. b Structural parameters of the tibial subchondral bone, analyzed according to trabecular bone volume/tissue volume (BV/TV), trabecular thickness (Tb. Th), and trabecular separation (Tb. Sp). Data are presented as mean ± SD from 10 samples. Data were analyzed using the one-way analysis of variance with the SNK post hoc test. *P < 0.05 vs. the DMM group. #P < 0.05 vs. the sham group