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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: CD14+CD16 monocytes are the main precursors of osteoclasts in rheumatoid arthritis via expressing Tyro3TK

Fig. 2

CD14+CD16 monocytes are the main osteoclast precursors in RA. Purified CD14+CD16+ and CD14+CD16 monocytes from RA (n = 5) and HC (n = 5) were cultured with rhM-CSF (30 ng/ml) and rhRANKL (50 ng/ml) for osteoclast differentiation. The cells were detected for tartrate-resistant acid phosphatase (TRAP) staining on day 17, and the TRAP-positive multinuclear cells were osteoclasts. The representative charts and the statistical results were shown. a CD14+CD16+ versus CD14+CD16 monocytes in HC (*P = 0.026). b RA versus HC for CD14+CD16 monocytes (*P = 0.019). c RA versus HC for CD14+CD16+ monocytes. *P < 0.05; ns, not significant (Student’s t test, ac)

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