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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Long-term changes in renal function after treatment initiation and the importance of early diagnosis in maintaining renal function among IgG4-related tubulointerstitial nephritis patients in Japan

Fig. 2

Least squares means (95% CI) of eGFR (mL/min/1.73m2) at baseline (i.e., at treatment initiation) and months after treatment initiation according to CKD stage 3, stage 4, and stage 5 in patients with IgG4-related TIN (n = 24) based on linear mixed models. Significantly lower values of eGFR were observed in patients with CKD stage 4 compared to patients with CKD stage 3. Patients with CKD stage 5 had comparatively lower eGFR than patients with CKD stage 3. Those mean differences in eGFR correspond to Table 4. On the other hand, there were no significant difference in change rates of eGFR (i.e., eGFR slope) among the patients with CKD stage 3, CKD stage 4, and CKD stage 5 (the mean difference of the monthly slope of the eGFR [95% CI], 0.0 [− 0.1 to 0.2] in CKD stage 4 and 0.1 [− 0.1 to 0.2] in CKD stage 5 compared with CKD stage 3 in model 2), meaning the mean differences of eGFR were stable during the clinical courses (baseline to 60 months). Abbreviations: CI, confidence interval; CKD, chronic kidney disease; TIN, tubulointerstitial nephritis; eGFR, estimated glomerular filtration rate

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Arthritis Research & Therapy

ISSN: 1478-6362

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