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Table 4 Mean differences (95% CI) in eGFR at each time point between CKD stage and histological stage obtained by linear mixed models

From: Long-term changes in renal function after treatment initiation and the importance of early diagnosis in maintaining renal function among IgG4-related tubulointerstitial nephritis patients in Japan

Months after treatment

Baselined

1

2

6

12

24

36

60

Mean differences (ml/min/1.73 m2)

Model 1a

 CKD stage 3

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 CKD stage 4

− 19.2 (− 25.2, − 13.1)

− 19.2 (− 25.1, − 13.2)

− 19.1 (− 25, − 13.2)

− 19.0 (− 24.6, − 13.4)

− 18.8 (− 24.1, − 13.6)

− 18.5 (− 23.5, − 13.5)

− 18.2 (− 23.5, − 12.9)

− 17.5 (− 24.7, − 10.3)

 CKD stage 5

− 26.2 (− 33.3, − 19.1)

− 26.2 (− 33.2, − 19.1)

− 26.1 (− 33.1, − 19.1)

− 25.9 (− 32.7, − 19.1)

− 25.6 (− 32.1, − 19.1)

− 25.0 (− 31.2, − 18.7)

− 24.3 (− 30.8, − 17.8)

− 23.1 (− 31.2, − 15)

 Histological stage Ac

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 Histological stage B

− 13.9 (− 23.7, − 4.1)

− 13.9 (− 23.6, − 4.2)

− 13.9 (− 23.4, − 4.3)

− 13.8 (− 23.2, − 4.4)

− 13.6 (− 22.8, − 4.5)

− 13.4 (− 21.9, − 4.9)

− 13.1 (− 21.4, − 4.8)

− 12.6 (− 21.4, − 3.8)

Model 2b

 CKD stage 3

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 CKD stage 4

− 15.6 (− 21.6, − 9.5)

− 15.6 (− 21.5, − 9.6)

− 15.5 (− 21.4, − 9.6)

− 15.4 (− 21.1, − 9.7)

− 15.2 (− 20.6, − 9.7)

− 14.7 (− 20.1, − 9.3)

− 14.3 (− 20.2, − 8.4)

− 13.4 (− 21.3, − 5.5)

 CKD stage 5

− 22.9 (− 29.9, − 16.0)

− 22.9 (− 29.8, − 16.0)

− 22.8 (− 29.7, − 16.0)

− 22.6 (− 29.3, − 15.9)

− 22.3 (− 28.7, − 15.8)

− 21.6 (− 28.0, − 15.2)

− 20.9 (− 27.6, − 14.1)

− 19.5 (− 28.0, − 11.0)

 Histological stage Ac

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 Histological stage B

− 13.5 (− 23.1, − 4.0)

− 13.5 (− 23, − 4.1)

− 13.5 (− 22.9, − 4.1)

− 13.4 (− 22.5, − 4.4)

− 13.3 (− 21.9, − 4.7)

− 13.1 (− 21, − 5.1)

− 12.8 (− 20.4, − 5.3)

− 12.4 (− 20.3, − 4.4)

  1. Abbreviations: CI confidence interval, eGFR estimated glomerular filtration rate, CKD chronic kidney disease, Ref. reference group
  2. aModel 1 was adjusted for age at the renal biopsy, sex, and hemodialysis
  3. bModel 2 was model 1 with additional adjustment for diagnosis of IgG4-related TIN and difference in the number of days between the renal biopsy and the initiation of glucocorticoid treatment when the interested exposure was CKD stage. Model 2 was model 1 with additional adjustment for whether or not they were diagnosed with IgG4-related TIN at the initial examination when the interested exposure was histological stage
  4. cInterstitial fibrosis is more clearly seen in stage B than in stage A
  5. dThe baseline was the time of treatment initiation
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Arthritis Research & Therapy

ISSN: 1478-6362

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