Fig. 6

miR-431-5p regulated apoptosis and cell cycle progression via XIAP in RA FLSs. a, b Flow cytometry and quantification for total apoptosis using Annexin V-FITC and PI-stained HFLS-RA cells transfected with miR-431-5p inhibitor and/or siRNAs against XIAP for 48 h. c, d Flow cytometry and quantification of cell cycle progression using PI-stained HFLS-RA cells transfected with miR-431-5p inhibitor and/or siRNAs against XIAP for 48 h. Each experiment was performed independently in triplicates. **P < 0.01, ***P < 0.001, ****P < 0.0001, compared with the NC groups