Table 3 Univariate and multivariate Cox regression analysis of the relapse factors among the patients in this study

 Age at onset

0.997 (0.980–1.015)

0.767

–

–

 Sex (male)

0.941 (0.598–1.483)

0.795

–

–

 Disease duration

1.000 (0.994–1.005)

0.920

–

–

 Allergy disease

1.223 (0.795–1.879)

0.360

–

–

 Number of affected organs

1.015 (0.897–1.148)

0.819

–

–

 RI scores

0.991 (0.952–1.030)

0.641

–

–

 Serum IgE level > 60 KU/L

2.495 (1.010–6.166)

0.048*

1.643 (0.711–3.798)

0.246

  ≤ 125 KU/L

Ref.

Ref.

–

–

  > 125 KU/L

2.068 (1.144–3.737)

0.016*

1.894 (1.022–3.508)

0.042*

  ≤ 0.5 × 10⁹/L

Ref.

Ref.

–

–

  > 0.5 × 10⁹/L

2.389 (1.502–3.799)

< 0.001***

2.354 (1.478–3.750)

< 0.001***

  ≤ 3 ULN

Ref.

Ref.

–

–

  3 ULN < IgG4 ≤ 5 ULN

0.757 (0.348–1.644)

0.482

–

–

  > 5 ULN

1.158 (0.704–1.904)

0.563

–

–

 Lacrimal gland

1.832 (1.171–2.865)

0.008**

1.732 (1.053–2.849)

0.031*

 Submandibular gland

1.591 (1.021–2.480)

0.040*

1.097 (0.671–1.793)

0.711

 Parotid gland

1.134 (0.657–1.957)

0.652

–

–

 Pancreas

1.562 (0.976–2.501)

0.063

–

–

 Bile duct

1.384 (0.791–2.241)

0.254

–

–

 Lung

1.258 (0.788–2.008)

0.337

–

–

 Kidney

2.937 (1.075–8.023)

0.036*

2.793 (1.019–7.659)

0.046*