Table 4 Experimentally verified lncRNAs associated with IDD
LncRNA | Expression | Target(s) | Functions | Publication year | References |
|---|---|---|---|---|---|
TUG1 | ↑ | Wnt1/β-catenin, Bax& caspase-3 | ↑NP cell apoptosis ↓NP cell proliferation ↑ECM degradation | 2017 2017 2017 | [24] [24] [24] |
GAS5 | ↑ | miR-155 | ↑NP cell apoptosis | 2019 | [103] |
LncPolE | ↑ | PolE | ↑NP cell apoptosis | 2019 | [100] |
HOTAIR | ↑ ↓ | AMPK/mTOR/ULK1 miR-34a-5p | ↑NP cell apoptosis ↑ECM degradation ↓NP cell apoptosis | 2020 2020 2019 | [104] [104] [105] |
MALAT1 | ↓ | miR-503 | ↓NP cell apoptosis ↑NP cell proliferation ↓Inflammation | 2017 2017 2017 | [114] [114] [114] |
LINC00641 | ↑ | miR-153-3p | ↑NP cell autophagy | 2019 | [58] |
SNHG1 | ↑ | miR-326 | ↑NP cell proliferation | 2018 | [106] |
RP11-296A18.3 | ↑ | miR-138 | ↑NP cell proliferation ↑ECM synthesis | 2017 2017 | [10] [10] |
H19 | ↑ | miR-22 | ↓NP cell proliferation ↑ECM degradation | 2018 2018 | [107] [107] |
FAF1 | ↑ | Erk | ↑NP cell proliferation | 2018 | [116] |
FAM83H-AS1 | ↑ | Notch1 | ↑NP cell growth ↑ECM degradation | 2019 2019 | [112] [112] |
HCG18 | ↑ | miR-146a-5p | ↑NP cell apoptosis ↓NP cell proliferation | 2017 2017 | [108] [108] |
Linc00958 | ↑ | miR-203 | ↑NP cell proliferation ↑ECM degradation | 2019 2019 | [109] [109] |
RMRP | ↑ | miR-206 | ↑NP cell proliferation ↓ECM degradation | 2018 2018 | [25] [25] |
NEAT1 | ↑ | ERK1/2, MAPK | ↑ECM degradation | 2018 | [111] |
SLC20A1 | ↑ | miR-31-5p | ↑ECM degradation | 2019 | [110] |
Linc-ADAMTS5 | ↑ | SFPQ | ↓ECM degradation | 2017 | [113] |
ZFAS1 | ↑ | Associate with inflammation level | 2019 | [115] |