Skip to main content

Table 4 Experimentally verified lncRNAs associated with IDD

From: Emerging evidence on noncoding-RNA regulatory machinery in intervertebral disc degeneration: a narrative review

LncRNA Expression Target(s) Functions Publication year References
TUG1 Wnt1/β-catenin, Bax& caspase-3 ↑NP cell apoptosis
↓NP cell proliferation
↑ECM degradation
2017
2017
2017
[24]
[24]
[24]
GAS5 miR-155 ↑NP cell apoptosis 2019 [103]
LncPolE PolE ↑NP cell apoptosis 2019 [100]
HOTAIR
AMPK/mTOR/ULK1
miR-34a-5p
↑NP cell apoptosis
↑ECM degradation
↓NP cell apoptosis
2020
2020
2019
[104]
[104]
[105]
MALAT1 miR-503 ↓NP cell apoptosis
↑NP cell proliferation
↓Inflammation
2017
2017
2017
[114]
[114]
[114]
LINC00641 miR-153-3p ↑NP cell autophagy 2019 [58]
SNHG1 miR-326 ↑NP cell proliferation 2018 [106]
RP11-296A18.3 miR-138 ↑NP cell proliferation
↑ECM synthesis
2017
2017
[10]
[10]
H19 miR-22 ↓NP cell proliferation
↑ECM degradation
2018
2018
[107]
[107]
FAF1 Erk ↑NP cell proliferation 2018 [116]
FAM83H-AS1 Notch1 ↑NP cell growth
↑ECM degradation
2019
2019
[112]
[112]
HCG18 miR-146a-5p ↑NP cell apoptosis
↓NP cell proliferation
2017
2017
[108]
[108]
Linc00958 miR-203 ↑NP cell proliferation
↑ECM degradation
2019
2019
[109]
[109]
RMRP miR-206 ↑NP cell proliferation
↓ECM degradation
2018
2018
[25]
[25]
NEAT1 ERK1/2, MAPK ↑ECM degradation 2018 [111]
SLC20A1 miR-31-5p ↑ECM degradation 2019 [110]
Linc-ADAMTS5 SFPQ ↓ECM degradation 2017 [113]
ZFAS1   Associate with inflammation level 2019 [115]
  1. The expression, targets, and functions of lncRNAs related to IDD were displayed in Table 4. “↓” represents downregulation, while “↑” represents upregulation