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Table 1 Demographic and clinical characteristics of patients at the start of first bDMARD in all patients included in the analysis and separately for multi-refractory patients and non-refractory patients

From: Clinical predictors of multiple failure to biological therapy in patients with rheumatoid arthritis

 

Total, n = 112

Multi-refractory patients (MR-patients), n = 41

Non-refractory patients (NR-patients), n = 71

p value

Sex (female)

95 (84.8)

33 (80.5)

62 (87.3)

0.33

Smoking status

Never smoker

63 (56.3)

22 (53.7)

41 (57.7)

 

Smoker

  Past

23 (20.5)

12 (29.3)

11 (15.5)

0.17

  Current

26 (23.2)

7 (17.0)

19 (26.8)

BMI (kg/m2)

26.4 (5.1)

26.6 (5.9)

26.2 (4.6)

0.79

Age (years)

At diagnosis

43.7 (13.1)

43.0 (13.6)

44.2 (12.8)

0.63

At starting cDMARD

46.4 (12.8)

45.1 (13.5)

47.2 (12.4)

0.41

At starting bDMARD

52.6 (11.9)

49.9 (12.3)

54.1 (11.5)

0.07

Extra-articular manifestations

21 (18.8)

12 (29.3)

9 (12.7)

0.03*

Immunological parameters

Positive RF (IU/ml)

99 (88.4)

35 (85.4)

64 (90.1)

0.44

Positive ACPA (IU/ml)

94 (83.9)

33 (80.5)

61 (85.9)

0.45

Erosions

42 (37.5)

24 (58.5)

18 (25.4)

0.001*

Concomitant cDMARD

89 (79.5)

35 (85.4)

54 (76.1)

0.24

Number of previous cDMARDs

< 3

75 (66.9)

16 (39.2)

59 (83.1)

 

≥ 3

37 (33.1)

25 (60.8)

12 (16.9)

0.001*

Disease duration between diagnosis and bDMARD (years)

8.9 (7.7)

6.9 (6.8)

10.0 (8.1)

0.04*

Concomitant steroids

112 (100)

41 (100)

71 (100)

First bDMARD

TNFi

95 (84.8)

38 (92.7)

57 (80.3)

0.07

Non-TNFi

17 (15.2)

3 (7.3)

14 (19.7)

Prior to start 1st bDMARD

DAS-28

5.4 (1.1)

5.8 (1.2)

5.1 (1.0)

0.002*

Tender joint count

9.9 (7.1)

12.3 (7.7)

8.5 (6.2)

0.005*

Swollen joint count

8.3 (4.8)

9.8 (6.2)

7.4 (3.5)

0.02*

HAQ

9.9 (5.2)

11.9 (5.6)

5.5 (5.1)

0.003*

ESR (mm/h)

33.1 (20.2)

37.1 (21.4)

30.8 (19.3)

0.11

CRP (mg/dl)

12.4 (16.8)

16.7 (23.0)

10.1 (11.6)

0.05*

  1. * statistically significant
  2. Results are shown as mean (standard deviation) for continuous variables and absolute number (percentage) for categorical variables
  3. BMI body mass index, RF rheumatoid factor, ACPA anti-citrullinated peptide antibodies, cDMARD conventional disease-modifying antirheumatic drug, bDMARD biological disease-modifying antirheumatic drug, DAS-28 Disease Activity Score-28, HAQ Health Assessment Questionnaire, ESR erythrocyte sedimentation rate, CPR C-reactive protein