Fig. 2
Associations between HBM and incident and progressive OA and change in OA sub-phenotypes. Points for continuous outcomes represent the difference in mean outcome between individuals with and without HBM (for example, a beta of 1 for change in osteophyte score would represent a 1-point greater increase in summed osteophyte score, which is the equivalent of the appearance of one additional osteophyte over 8 years or the increase in the size of an osteophyte already present). Points for binary outcomes represent the odds ratio for individuals with HBM compared to their relatives with normal BMD. Model 1: unadjusted; model 2: adjusted for age, sex and follow-up time (plus baseline score for continuous outcomes); model 3: adjusted for age, sex, follow-up time, height and TBFM (plus baseline score for continuous outcomes). Nincident OA = 248; Ncontinuous outcomes = 263. Abbreviation: JSN joint space narrowing