Noncoding RNAs in subchondral bone osteoclast function and their therapeutic potential for osteoarthritis

Table 1 miRNAs in osteoclast function and survival

miRNAs	Species	Up/down	Overall impact	Targets	Steps impacted	References
miR-31	Mouse	Up	Positive	RhoA	Acting ring formation	[23]
miR-21	Mouse	Up	Positive	PTEN	Resorption	[24]
miR-146-5p	Human	Up	Positive	ND	Resorption	[25]
miR-34c	Mouse	Up	Positive	LGR4	Survival	[26]
miR-29b	Mouse	Up	Positive	Bmf	Survival	[27]
miR-539	Rat	Down	Positive	ND	Survival	[28]
miR-21	Mouse	Up	Negative	FASL	Survival	[29]
miR-21	Human	Up	Negative	OPG	Resorption	[30]
miR-26a	Mouse	ND	Negative	ND	Resorption	[31]
miR-29b	Human	Down	Negative	FOS; MMP-2	Acting ring formation	[32]
miR-30a	Mouse	Down	Negative	DC-STAMP	Acting ring formation	[33]
miR-9; miR-181a	Mouse	ND	Negative	Cbl	Survival, mobility	[34]
miR-142-3p	Human	Down	Negative	PRKCA	Survival	[35]
miR-186	Mouse	ND	Negative	CTSK	Survival	[36]
miR-193-3p	Mouse	ND	Negative	NFATc1	Resorption	[37]
miR-338-3p	Mouse	Down	Negative	IKKβ	Resorption	[38]

ISSN: 1478-6362