# Table 4 Characteristics of subgroups

Variable Group 1 (n = 680) Group 2 (n = 388) Group 3 (n = 457) Group 4 (n = 500) Group 5 (n = 229) Group 6 (n = 288) Total (n = 2542)
Age, years 68.1 (5.1) 67.8 (5.0) 68.8 (5.2) 69.9 (5.2) 68.2 (5.2) 69.4 (5.08) 68.7 (5.2)
Female, n, % 439, 64.6 136, 35.1 253, 55.4 421, 84.2 176, 76.9 200, 69.4 1625, 63.9
BMI, kg/m2 20.5 (2.1) 22.9 (2.3) 22.7 (2.3) 21.5 (2.0) 21.7 (3.2) 27.4 (2.6) 22.4 (3.1)
K/L grade 0 61, 9.0 13, 3.4 21, 4.6 0, 0 8, 3.5 0, 0 103, 4.1
K/L grade 1 619, 91.0 291, 75.0 369, 80.7 0, 0 140, 61.1 46, 16.0 1465, 57.6
K/L grade 2 0, 0 76, 19.6 63, 13.8 371, 74.2 62, 27.1 163, 56.6 735, 28.9
K/L grade 3 0, 0 8, 2.1 4, 0.9 114, 22.8 18, 7.9 72, 25.0 216, 8.5
K/L grade 4 0, 0 0, 0 0, 0 15, 3.0 1, 0.4 7, 2.4 23, 0.9
MHI-5 score 71 (8.1) 73 (7.9) 71 (8.4) 71 (8.3) 44 (7.5) 72 (8.6) 69 (11.3)
Depressive symptoms, n, % 0, 0 0, 0 0, 0 0, 0 229, 100 0, 0 229, 9.0
hs-CRP mean (SD), median, μg/ml 0.26 (0.16), 0.22 0.77 (1.17), 0.48 2.43 (3.71), 1.14 0.38 (0.35), 0.27 0.93 (3.05), 0.38 1.14 (1.52), 0.66 0.91 (2.1), 0.41
BMD (T score) − 1.6 (0.63) 0.21 (0.76) − 1.7 (0.62) − 1.7 (0.68) − 1.4 (0.89) − 1.2 (0.72) − 1.3 (0.95)
1. Values are mean (SD), except where otherwise indicated
2. Percentages may not sum to 100 because of rounding
3. Scores on the MHI-5 range from 0 to 100, with higher scores indicating better mental health. MHI-5 ≤ 52 were considered as having depressive symptoms
4. Defined groups are 1 = “minimal joint disease subgroup,” 2 = “male and high BMD subgroup,” 3 = “high CRP subgroup,” 4 = “severe ROA subgroup,” 5 = “depressive subgroup,” and 6 = “moderate ROA with high BMI subgroup”
5. BMD bone mineral density, BMI body mass index, hs-CRP high-sensitivity C-reactive protein, K/L Kellgren/Lawrence, MHI-5 Mental Health Inventory-5, ROA radiographic knee OA