Fig. 3

Synoviocytes were cultured with or without various concentration of PCSK9 in the presence or absence of anti-PCSK9 antibodies for 24 h. Experiments were performed three times and triplicate in each time. The mean value of 3 independent experiments was presented in the bar diagram. a PCSK9 induced level of MCP1 in the synoviocytes in a concentration-dependent manner (n = 9). b Synoviocytes were stimulated with 500 ng/ml of PCSK9 in the presence or absence of 5 μg/ml of anti-PCSK9 antibodies for 24 h, and the level of MCP1 was inhibited by anti-PCSK9 antibodies (n = 9). P value ≤ 0.0005 was considered *** and ≤ 0.0001 was condsidered as ****