C1 (n = 62) | C2 (n = 598) | C3 (n = 124) | C4 (n = 491) | |
---|---|---|---|---|
Female, n (%) | 52 (83.9%) | 431 (72.1%) | 102 (82.3%) | 390 (79.4%) |
Age at diagnosis, years, median (IQR) | 44.0 (34.0–52.0) | 43.5 (33.0–52.0) | 45.0 (34.0–51.5) | 47.0 (38.0–54.0) |
Age at start of 1st line, years, median (IQR) | 51.0 (42.0–58.0) | 53.0 (41.0–60.0) | 52.0 (44.5–61.0) | 55.0 (48.0–63.0) |
Disease duration, years, median (IQR) | 5.6 (3.0–7.8) | 6.0 (2.5–11.8) | 5.0 (2.2–12.1) | 6.2 (3.0–12.9) |
RF positive, n (%) | 47 (75.8%) | 428 (71.6%) | 92 (74.2%) | 389 (79.6%) |
ACPA positive, n/total (%) | 44/61 (72.1%) | 399/587 (68.0%) | 91/120 (75.8%) | 348/480 (72.5%) |
Presence of erosions, n/total (%) | 25/38 (65.8%) | 210/295 (71.2%) | 46/67 (68.7%) | 22/290 (76.6%) |
Currently smoking, n/total (%) | 10/53 (18.9%) | 102/504 (20.2%) | 26/103 (25.2%) | 93/413 (22.5%) |
Number of previous csDMARDs, n (%) | ||||
0 | 0 (0.0%) | 8/592 (1.4%) | 2 (1.6%) | 6/484 (1.2%) |
1 | 13 (21.0%) | 226/592 (38.2%) | 27 (21.8%) | 131/484 (27.1%) |
2 | 18 (29.0%) | 147/592 (24.8%) | 30 (24.2%) | 165/484 (34.1%) |
3 | 17 (27.4%) | 112/592 (18.9%) | 35 (28.2%) | 113/484 (23.3%) |
4+ | 14 (22.6%) | 99/592 (16.7%) | 30 (24.2%) | 69/484 (14.3%) |
Glucocorticoids in previous history, n (%) | 56 (90.3%) | 519/597 (86.9%) | 112 (90.3%) | 442 (90.0%) |
Concomitant csDMARDs, n (%) | 54 (87.1%) | 549 (91.8%) | 107 (86.3%) | 440 (89.6%) |
Concomitant MTX, n (%) | 44 (71.0%) | 454 (75.9%) | 77 (62.1%) | 349 (71.1%) |
Concomitant GCs, n (%) | 49 (79.0%) | 446 (74.6%) | 96 (77.4%) | 402 (81.9%) |
DAS28-ESR (0–10), median (IQR) | 6.4 (5.7–7.0) | 5.9 (5.3–6.5) | 6.2 (5.6–6.8) | 6.3 (5.8–6.8) |
TJC (28 joints), median (IQR) | 14.0 (11.0–19.0) | 12.0 (9.0–16.0) | 14.5 (9.0–19.0) | 13.0 (10.0–18.0) |
SJC (28 joints), median (IQR) | 10.0 (7.0–13.0) | 9.0 (6.0–12.0) | 9.5 (6.0–12.5) | 10.0 (7.0–13.0) |
ESR (mm/h), median (IQR)a | 33.5 (16.0–53.0) | 28.0 (16.0–40.0) | 32.0 (18.0–50.0) | 34.0 (23.0–50.0) |
CRP (mg/l), median (IQR)b | 22.0 (9.4–34.0) | 12.0 (5.3–23.5) | 15.0 (7.9–31.0) | 16.8 (8.0–33.1) |
SDAI (0–86), median (IQR)c | 40.5 (32.7–47.8) | 35.6 (29.5–42.4) | 39.3 (33.0–48.2) | 39.0 (32.6–45.9) |
PTGA (0–100), median (IQR) | 78.0 (69.0–84.0) | 70.0 (59.0–80.0) | 75.0 (62.5–81.5) | 75.0 (60.0–85.0) |
MDGA (0–100), median (IQR)d | 74.0 (60.0–80.0) | 65.0 (52.0–75.0) | 70.0 (58.5–80.0) | 70.0 (60.0–80.0) |
HAQ-DI (0–3), median (IQR) | 1.8 (1.3–2.0) | 1.4 (1.0–1.8) | 1.8 (1.4–2.0) | 1.8 (1.4–2.0) |
EQ-5D (− 0.59–1), median (IQR) | 0.1 (0.0–0.6) | 0.2 (0.1–0.7) | 0.1 (0.0–0.5) | 0.1 (0.0–0.5) |