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Table 5 Association between miR-143 rs353299 C/T polymorphism and MCTD clinical parameters

From: Association study between immune-related miRNAs and mixed connective tissue disease

Swollen fingers or hands
miR-143 rs353299 C/T n (%) Model p OR 95% CI
  Genotype CC CT TT TT + CT vs CC 0.25 1.87 0.36 9.83
   Swollen fingers or hands 31 (91.18) 46 (100) 12 (80) CC + CT vs TT 0.07 0.16 0.03 0.86
   Without swollen fingers or hands 3 (8.82) 0 (0) 3 (20) TT + CC vs CT 0.07 13.8966 0.7600 254.09
  Allele C T   TT vs CC 0.28 0.39 0.07 2.19
   Swollen fingers or hands 108 (95) 70 (92)   CT vs CC 0.12 10.33 0.5157 207.0449
   Without swollen fingers or hands 6 (5) 6 (8)   C vs T 0.4679 0.65 0.2 2.09
Lymphadenopathy
miR-143 rs353299 C/T n (%) Model p OR 95% CI
  Genotype CC CT TT TT + CT vs CC 0.35 1.81 0.67 4.87
   Lymphadenopathy 7 (20) 18 (39) 1 (7) CC + CT vs TT 0.06 0.16 0.02 1.28
   Without lymphadenopathy 28 (80) 28 (61) 14 (93) TT + CC vs CT 0.02 3.38 1.29 8.82
  Allele C T   TT vs CC 0.26 0.29 0.03 2.56
   Lymphadenopathy 32 (28) 20 (26)   CT vs CC 0.07 2.57 0.93 7.12
   Without lymphadenopathy 84 (72) 56 (74)   C vs T 0.84 0.94 0.49 1.8
Pericarditis/pleuritis
miR-143 rs353299 C/T n (%) Model p OR 95% CI
  Genotype CC CT TT TT + CT vs CC 0.85 20.14 6.58 61.68
   Pericarditis/pleuritis 5 (14.29) 41 (89) 6 (40) CC + CT vs TT 0.02 0.51 0.17 1.56
   Without pericarditis/pleuritis 30 (85.71) 5 (11) 9 (60) TT + CC vs CT 0.18 29.07 9.26 91.31
  Allele C T   TT vs CC 0.05 4 0.99 16.24
   Pericarditis/pleuritis 51 (44) 53 (70)   CT vs CC < 0.0001 49.2 13.06 185.29
   Without pericarditis/pleuritis 65 (56) 23 (30)   C vs T 0.0006 2.94 1.59 5.41
  1. n number of patients with clinical information; p value < 0.05 is considered significant, indicated in bold; p value obtained from χ2 or Fisher exact test