Association study between immune-related miRNAs and mixed connective tissue disease

Table 5 Association between miR-143 rs353299 C/T polymorphism and MCTD clinical parameters

*Swollen fingers or hands*
miR-143 rs353299 C/T	n (%)			Model	p	OR	95% CI
Genotype	CC	CT	TT	TT + CT vs CC	0.25	1.87	0.36	9.83
Swollen fingers or hands	31 (91.18)	46 (100)	12 (80)	CC + CT vs TT	0.07	0.16	0.03	0.86
Without swollen fingers or hands	3 (8.82)	0 (0)	3 (20)	TT + CC vs CT	0.07	13.8966	0.7600	254.09
Allele	C	T		TT vs CC	0.28	0.39	0.07	2.19
Swollen fingers or hands	108 (95)	70 (92)		CT vs CC	0.12	10.33	0.5157	207.0449
Without swollen fingers or hands	6 (5)	6 (8)		C vs T	0.4679	0.65	0.2	2.09
*Lymphadenopathy*
miR-143 rs353299 C/T	n (%)			Model	p	OR	95% CI
Genotype	CC	CT	TT	TT + CT vs CC	0.35	1.81	0.67	4.87
Lymphadenopathy	7 (20)	18 (39)	1 (7)	CC + CT vs TT	0.06	0.16	0.02	1.28
Without lymphadenopathy	28 (80)	28 (61)	14 (93)	TT + CC vs CT	0.02	3.38	1.29	8.82
Allele	C	T		TT vs CC	0.26	0.29	0.03	2.56
Lymphadenopathy	32 (28)	20 (26)		CT vs CC	0.07	2.57	0.93	7.12
Without lymphadenopathy	84 (72)	56 (74)		C vs T	0.84	0.94	0.49	1.8
*Pericarditis/pleuritis*
miR-143 rs353299 C/T	n (%)			Model	p	OR	95% CI
Genotype	CC	CT	TT	TT + CT vs CC	0.85	20.14	6.58	61.68
Pericarditis/pleuritis	5 (14.29)	41 (89)	6 (40)	CC + CT vs TT	0.02	0.51	0.17	1.56
Without pericarditis/pleuritis	30 (85.71)	5 (11)	9 (60)	TT + CC vs CT	0.18	29.07	9.26	91.31
Allele	C	T		TT vs CC	0.05	4	0.99	16.24
Pericarditis/pleuritis	51 (44)	53 (70)		CT vs CC	< 0.0001	49.2	13.06	185.29
Without pericarditis/pleuritis	65 (56)	23 (30)		C vs T	0.0006	2.94	1.59	5.41

n number of patients with clinical information; p value < 0.05 is considered significant, indicated in bold; p value obtained from χ² or Fisher exact test

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