Predictors of radiographic erosion and joint space narrowing progression in patients with early rheumatoid arthritis: a cohort study

Rydell, Emil; Forslind, Kristina; Nilsson, Jan-Åke; Karlsson, Magnus; Åkesson, Kristina E.; Jacobsson, Lennart T. H.; Turesson, Carl

doi:10.1186/s13075-020-02413-7

Table 3 Baseline predictors of erosion score progression up to 5 years

From: Predictors of radiographic erosion and joint space narrowing progression in patients with early rheumatoid arthritis: a cohort study

	Crude		Adjusted^a
	β	95% CI	β	95% CI
Demographics
Male sex	0.08	− 0.03, 0.20	0.06	− 0.04, 0.17
Age (per SD)^b	0.02	− 0.03, 0.08	0.02	− 0.03, 0.07
Time to first DMARD (per SD)^b	0.01	− 0.04, 0.06	0.01	− 0.04, 0.05
Smoking habits
Never smoker (reference)	0.00		0.00
Current smoker	0.17	0.04, 0.30	0.12	− 0.00, 0.24
Previous smoker	0.15	0.03, 0.27	0.12	0.01, 0.23
Ever smoker	0.16	0.05, 0.27	0.12	0.02, 0.22
Baseline disease parameters
RF positivity	0.23	0.13, 0.34	0.24^c	0.14, 0.34^c
Anti-CCP positivity	0.23	0.12, 0.33	0.13	0.02, 0.24
COMP titer (per SD)^b	0.04	− 0.01, 0.10	0.04	− 0.01, 0.09
COMP > 12 units/l	0.10	− 0.01, 0.21	0.12	0.02, 0.22
Erosions present^d	0.21	0.08, 0.34	0.16^e	0.03, 0.29
Erosion score (per SD)^b	0.07	0.02, 0.12	0.08^e	0.03, 0.12
Joint space narrowing score (per SD)^b	0.04	− 0.01, 0.09	0.04^e	− 0.01, 0.08
DAS28 (per SD)^b	0.05	0.001, 0.11	0.04	− 0.01, 0.08
Disease activity^d
Low/moderate (reference)	0.00		0.00
High	0.15	0.05, 0.25	0.11	0.01, 0.21
HAQ (per SD)^b	0.03	− 0.02, 0.08	0.03	− 0.02, 0.07
ESR (per SD)^b	0.11	0.06, 0.16	0.08	0.03, 0.12
CRP below median (reference)	0.00		0.00
CRP above median (> 9 mg/l)	0.15	0.06, 0.25	0.09	− 0.01, 0.18
Swollen joint count (per SD)^b	0.03	− 0.02, 0.09	0.03	− 0.02, 0.08
Tender joint count (per SD)^b	− 0.03	− 0.09, 0.03	− 0.02	− 0.07, 0.04
Patient’s global assessment (VAS; per SD)^b	0.05	− 0.01, 0.10	0.03	− 0.02, 0.08
Pain (VAS; per SD)^b	0.02	− 0.03, 0.08	0.02	− 0.02, 0.07

Numbers in bold indicate significance of p ≤ 0.05
CI confidence interval, SD standard deviation, DMARD disease-modifying anti-rheumatic drug, RF rheumatoid factor, Anti-CCP anti-citrullinated peptide antibodies, COMP cartilage oligomeric matrix protein, DAS28 disease activity score of 28 Joints, HAQ health assessment questionnaire, ESR erythrocyte sedimentation rate, CRP C-reactive protein, VAS visual analogue scale
^aAdjusted for RF and baseline erosion score
^bSD: age 14 years; time to first DMARD 5.8 months; COMP 3.6 units/l; erosion score 3; JSN score 8; DAS28 1.4; HAQ 0.64; ESR 26 mm/h; swollen joint count 4.8; tender joint count 5.8; patient’s global assessment 26; pain 26
^cAdjusted for baseline erosion score
^dFor definitions see Table 1
^eAdjusted only for RF

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