Table 2 Univariable GEE associations of global rating of change status with SLEQOL, SF36 surveys and clinical indicators
GRC status | Outcomes | ||||||
HRQoL surveys | SLE clinical indicators (present at visit) | ||||||
SLEQOL (SLE-specific) | SF36 (generic) | In LLDAS | SLEDAI-2K > 4 | MM/S flare | Organ damage | ||
PCS | MCS | ||||||
Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Freq. visits (%) | Freq. visits (%) | Freq. visits (%) | Freq. visits (%) | |
No change (no. visits = 471) | 88.4 (87.2, 89.7) | 46.9 (46.1, 47.8) | 49.5 (48.6, 50.5) | 219 (46.6%) | 127 (27.0%) | 82 (17.4%) | 215 (45.6%) |
Deterioration (no. visits = 250) | 79.6 (77.4, 81.7) | 42.8 (41.8, 43.8) | 47 (45.7, 48.2) | 82 (32.8%) | 97 (38.8%) | 66 (26.4%) | 157 (62.8%) |
Improvement (no. visits = 1007) | 88.8 (87.7, 89.9) | 47.9 (47.2, 48.7) | 50.1 (49.2, 50.9) | 525 (52.2%) | 259 (25.7%) | 130 (12.9%) | 517 (51.3%) |
Mean diff. (95% CI), p value | Mean diff. (95% CI), p value | Mean diff. (95% CI), p value | Odds ratio (95% CI), p value | Odds ratio (95% CI), p value | Odds ratio (95% CI), p value | Odds ratio (95% CI), p value | |
No change (ref.) | 0 | 0 | 0 | 1.00 | 1.00 | 1.00 | 1.00 |
Deterioration | − 8.9 (−11.1, − 6.7), p < 0.01 | − 4.12 (− 5.2, − 3.1), p < 0.01 | − 2.53 (− 3.9, − 1.2), p < 0.01 | 0.59 (0.43, 0.80), p < 0.01 | 1.61 (1.18, 2.19), p < 0.01 | 1.83 (1.27, 2.64), p < 0.01 | 1.12 (1.01, 1.25), p = 0.04 |
Improvement | 0.4 (− 0.5, 1.3), p = 0.4 | 0.96 (0.3,1.6), p < 0.01 | 0.54 (− 0.2,1.3), p = 0.17 | 1.30 (1.07, 1.57), p = 0.01 | 0.85 (0.70, 1.04), p = 0.11 | 0.70 (0.52, 0.95), p = 0.02 | 1.01 (0.93, 1.10), p = 0.8 |