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Table 3 Predictors of LUNDEX-corrected EULAR good response. Odds ratios (95% confidence intervals)

From: Abatacept in rheumatoid arthritis: survival on drug, clinical outcomes, and their predictors—data from a large national quality register

 

6 months

12 months

Univariate

Multivariate

Univariate

Multivariate

Male sex

2.11 (1.41–3.13)

2.28 (1.45–3.57)

2.46 (1.71–3.54)

2.14 (1.44–3.19)

≥ 2 bDMARDs

Reference (1.0)

Reference (1.0)

Reference (1.0)

Reference (1.0)

Bionaïve

4.00 (2.60–6.15)

3.59 (2.25–5.72)

4.45 (2.95–6.71)

4.29 (2.77–6.65)

1 bDMARD

1.11 (0.72–1.72)

*

1.11 (0.74–1.69)

**

DAS28-CRP (per SD) at baseline

0.95 (0.80–1.14)

*

0.98 (0.83–1.16)

**

DAS28 (per unit) at baseline

0.91 (0.79–1.04)

*

0.97 (0.85–1.10)

**

VAS pain (per SD) at baseline

0.96 (0.80–1.15)

*

0.89 (0.75–1.06)

**

Methotrexate at baseline

1.36 (0.95–1.94)

*

1.46 (1.04–2.06)

**

HAQ score (per SD) at baseline

0.64 (0.52–0.77)

0.75 (0.61–0.93)

0.65 (0.54–0.78)

0.74 (0.61–0.90)

Disease duration (per SD) at baseline

0.79 (0.65–0.96)

*

0.72 (0.59–0.87)

**

Age (per SD) at baseline

0.76 (0.65–0.91)

0.79 (0.65–0.96)

0.97 (0.82–1.14)

**

Glucocorticoids at baseline

0.59 (0.42–0.83)

0.59 (0.40–0.86)

0.72 (0.52–1.00)

**

csDMARD at baseline

1.40 (0.96–2.06)

*

1.25 (0.87–1.79)

**

s.c. abatacept administration

Reference (1.0)

*

Reference (1.0)

**

i.v. abatacept administration

0.53 (0.38–0.75)

*

0.70 (0.51–0.98)

**

  1. *Not included in the final model. The first multivariate model in the stepwise analysis included sex, bDMARD exposure, DAS28, methotrexate at baseline, HAQ-DI, disease duration, age, glucocorticoids at baseline, csDMARDs at baseline, and route of abatacept administration. **Not included in the final model. The first multivariate model in the stepwise analysis included sex, bDMARD exposure, methotrexate at baseline, HAQ-DI, disease duration, glucocorticoids at baseline, and route of abatacept administration. Multivariate model includes 754 patients at 6 months, 829 patients at 12 months