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Table 3 Adjusted hazard ratios (aHR) and 95% confidence intervals (CI) for comorbid conditions, individually, on modeled transition states, over the full follow-up period, by sex

From: Comorbid conditions and the transition among states of hip osteoarthritis and symptoms in a community-based study: a multi-state time-to-event model approach

StrataType of transitionObesity (vs no obesity)1DM (vs no DM)1CVD (vs no CVD)1
 n (vs n) for transitions
 aHR (95% CI)
WomenDevelopment of rHOA
 No rHOA/symptoms (A) to rHOA (B)56 (vs 77)25 (vs 108)49 (vs 84)
0.85 (0.59, 1.21)1.03 (0.61, 1.75)1.42 (0.98, 2.05)
 Symptoms only (C) to sxHOA (D)28 (vs 21)13 (vs 36)32 (vs 17)
1.27 (0.73, 2.20)1.42 (0.74, 2.75)1.23 (0.70, 2.17)
Development of symptoms
 No rHOA/symptoms (A) to symptoms only (C)108 (vs 77)39 (vs 146)64 (vs 121)
1.44 (1.02, 2.02)0.92 (0.56, 1.50)1.22 (0.83, 1.79)
 rHOA (B) to sxHOA (D)55 (vs 59)26 (vs 88)51 (vs 63)
0.70 (0.43, 1.13)1.42 (0.78, 2.61)0.94 (0.58, 1.54)
Resolution of symptoms
 Symptoms only (C) to no rHOA/symptoms (A)122 (vs 86)48 (vs 160)75 (vs 133)
0.93 (0.68, 1.27)0.78 (0.49, 1.22)0.60 (0.42, 0.87)
 sxHOA (D) to rHOA (B)69 (vs 49)26 (vs 92)52 (vs 66)
0.71 (0.44, 1.13)0.86 (0.48, 1.54)0.60 (0.38, 0.94)
MenDevelopment of rHOA
 No rHOA/symptoms (A) to rHOA (B)26 (vs 39)14 (vs 51)20 (vs 45)
0.93 (0.55, 1.57)1.10 (0.52, 2.31)1.08 (0.53, 2.19)
 Symptoms only (C) to sxHOA (D)10 (vs 6)5 (vs 11)9 (vs 7)
2.14 (0.88, 5.21)1.26 (0.46, 3.47)0.68 (0.21, 2.17)
Development of symptoms
 No rHOA/symptoms (A) to symptoms only (C)48 (vs 56)25 (vs 79)44 (vs 60)
1.15 (0.74, 1.79)1.32 (0.71, 2.45)1.26 (0.75, 2.13)
 rHOA (B) to sxHOA (D)32 (vs 26)13 (vs 45)20 (vs 38)
1.50 (0.78, 2.88)0.81 (0.33, 2.03)1.46 (0.65, 3.28)
Resolution of symptoms
 Symptoms only (C) to no rHOA/symptoms (A)42 (vs 51)19 (vs 74)32 (vs 61)
0.78 (0.49, 1.24)0.70 (0.38, 1.30)0.61 (0.36, 1.05)
 sxHOA (D) to rHOA (B)35 (vs 21)12 (vs 44)20 (vs 36)
1.15 (0.60, 2.21)0.28 (0.10, 0.81)1.12 (0.54, 2.33)
  1. 1Model includes effects for baseline values of birth year, study cohort, age, race, and education and time-dependent values of obesity, DM, CVD, and hip injury
  2. Italics indicate statistical significance (i.e., the 95% CI excludes 1)