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Table 4 Associations between clinical and patient-reported outcomes and US-detected inflammation: synovitis (GLOESS) and tenosynovitis

From: Serial magnetic resonance imaging and ultrasound examinations demonstrate differential inflammatory lesion patterns in soft tissue and bone upon patient-reported flares in rheumatoid arthritis

 Univariate modelFull multivariate modelMultivariate model after backward selection
Coefficient (95% CI)pCoefficient (95% CI)pCoefficient (95% CI)p
US synovitis (GLOESS)
 Flare1.58 (0.35; 2.82)0.011.12 (− 0.58; 2.80)0.19  
 SJC280.81 (0.19; 1.43)0.010.78 (0.00; 1.50)0.0490.83 (0.20;1.45)0.009
 CRP0.09 (− 0.01; 0.18)0.0560.02 (− 0.09; 0.12)0.73  
 Pain (VAS)0.02 (− 0.02; 0.05)0.330.006 (− 0.05; 0.07)0.85  
 PGA (VAS)0.01 (− 0.02; 0.04)0.55− 0.02 (− 0.09; 0.04)0.45  
 HAQ− 0.23 (− 2.24; 1.78)0.82− 0.83 (− 3.27; 1.60)0.50  
US tenosynovitis
 Flare1.44 (0.55; 2.32)0.00151.35 (0.08; 2.61)0.037  
 SJC280.82 (0.37; 1.27)0.00030.70 (0.14; 1.27)0.0150.82 (0.38; 1.27)< 0.0001
 CRP0.09 (0.01; 0.16)0.030.03 (− 0.05; 0.12)0.41  
 Pain (VAS)0.01 (− 0.01; 0.04)0.23− 0.01 (− 0.06; 0.03)0.57  
 PGA (VAS)0.01 (− 0.01; 0.04)0.32− 0.01 (− 0.05; 0.04)0.80  
 HAQ− 0.08 (− 1.70; 1.54)0.92− 1.02 (− 3.00; 0.94)0.30  
  1. CRP C-reactive protein, GLOESS Global OMERACT (Outcome Measures in Rheumatology)-EULAR (European League Against Rheumatism) Synovitis Score, HAQ health assessment questionnaire, PGA patient’s global assessment, SJC28 swollen joint count assessed in 28 joints, US ultrasonography, VAS visual analog scale; all multivariate mixed effect linear regression models are adjusted for age, sex, and disease duration at baseline
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