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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Resolvin D1 suppresses pannus formation via decreasing connective tissue growth factor caused by upregulation of miRNA-146a-5p in rheumatoid arthritis

Fig. 5

RvD1 decreased the expression of pro-inflammatory cytokines in RA FLS. a–d The transcription levels of IL-6 gene, IL-1β gene, TNF-α gene, and CTGF gene in RA FLS treated with RvD1 (0, 20, and 100 nmol) were determined by qRT-PCR. d–g The concentrations of IL-6, IL-1β, TNF-α, and CTGF in the supernatant from RA FLS-treated RvD1 were detected by ELISA. Control, RA FLS were treated with PBS; 20 nmol RvD1, RA FLS were treated with 20 nmol RvD1; 100 nmol RvD1, RA FLS were treated with 100 nmol RvD1. All data were represented as the mean ± SD. The differences among three groups were assessed by one-way ANOVA

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