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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: A bioavailable form of curcumin, in combination with vitamin-D- and omega-3-enriched diet, modifies disease onset and outcomes in a murine model of collagen-induced arthritis

Fig. 5

Combination of CUR and VO-enriched diet maximally altered the serum cytokine/chemokine profile in CIA mice. Saline control and CIA mice under different conditions as indicated were euthanized by cardiac puncture under anesthesia on day 29 after the first CII challenge. Concentrations of a panel of 29 cytokines/cytokines were examined in serum, using the V-PLEX mouse multiplex Meso Scale Discovery (MSD) assay kit. Intensity for each analyte was log2 transformed and normalized across each row. The heatmap shows differentially expressed cytokines and chemokines for all samples (n = 10 per group), where each column shown represents one mouse (green to red ranges from − 2 to + 2 intensities respectively)

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Arthritis Research & Therapy

ISSN: 1478-6362

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