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Table 1 Baseline characteristics of patients in the included studies

From: Risk factors for mortality of diffuse alveolar hemorrhage in systemic lupus erythematosus: a systematic review and meta-analysis

No.

Author, year

Country

Study population

Study type

Time span

Number of patients (gender)

Prognostic factors

Mortality rate (%)

NOS score

1

Zamora, 1997

USA

SLE patients from a single cohort

Retrospective cohort study

1984–1994

15 (10 females, 5 male)

CTX treatment, mechanical ventilator, infection

42.1

8

2

Chang, 2002

China

SLE patients from a single cohort

Retrospective cohort study

1994–2001

8 (all females)

APACHE II score, OSF score

50.0

8

3

Badsha, 2004

Singapore

SLE patients from a single cohort

Retrospective cohort study

1994–2001

22 (20 females, 2 males)

SLEDAI, SLAM

36.4

8

4

Kwok, 2011

South Korea

SLE patients from a single cohort

Retrospective cohort study

1993–2009

21 (19 females, 2 males)

Mechanical ventilator, infection

61.9

9

5

Martínez-Martínez, 2014

Mexico

SLE patients from 9 cohorts

Retrospective cohort study

NA

50 patients with 57 episodes (49 females, 8 males)

Creatinine, platelets, APACHE II score, mechanical ventilator, infection

42.1

8

6

Kim, 2017

South Korea

SLE patients from a single cohort

Retrospective cohort study

2004–2014

24 (all females)

Lupus nephritis, plasmapheresis, transfusion, mechanical ventilator

29.2

9

7

Quintana, 2019

Colombia

SLE patients from a single cohort

Retrospective cohort study

2011–2018

17 (11 females, 6males)

Disease duration, albumin, SLEDAI, inotropic/vasoactive use, mechanical ventilator

29.4

7

8

Sun, 2020

China

SLE patients from a single cohort

Retrospective cohort study

2004–2019

94 (82 females, 12 males)

Lupus nephritis, platelets, CTX treatment, mechanical ventilator

38.3

9

  1. NOS Newcastle-Ottawa Scale, SLE systemic lupus erythematosus, CTX cyclophosphamide, APACHE II Acute Physiology, Age, and Chronic Health Evaluation, OSF organ system failure, SLEDAI systemic lupus erythematosus activity index, SLAM systemic lupus activity measure, NA not available