Table 1 Characteristics of study cohorts
Risk factors | Cohort 1 (US-based) | Cohort 2 (UK-based) | Cohort 3 (UK-based) | Gout cohort (UK-based) | ||||
|---|---|---|---|---|---|---|---|---|
Normouricaemia (n = 11,883) | Hyperuricaemia (n = 2364) | Normouricaemia (n = 52,782) | Hyperuricaemia (n = 4469) | Normouricaemia (n = 317,414) | Hyperuricaemia (n = 30,112) | Normouricaemia (n = 4574) | Hyperuricaemia (n = 2207) | |
Sex - male | 4967 (41.8) | 1872 (79.2) | 21,493 (40.7) | 3848 (86.1) | 131,853 (41.5) | 25,508 (84.7) | 4139 (90.5) | 2124 (96.2) |
BMI ≥25 kg/m2 | 6320 (53.2) | 1993 (84.3) | 32,651 (61.9) | 4033 (90.2) | 205,746 (64.8) | 27,189 (90.3) | 4154 (90.8) | 2046 (92.7) |
BMI, mean (SD) | 25.9 (4.6) | 29.1 (4.8) | 26.8 (4.6) | 30.2 (4.8) | 27.1 (4.6) | 30.4 (5.0) | 30.7 (5.0) | 30.7 (4.8) |
SLC2A9, rs12498742 A-allele present | 11,148 (93.8) | 2285 (96.7) | 49,619 (94.0) | 4358 (97.5) | 298,675 (94.1) | 29,336 (97.4) | 4473 (97.8) | 2171 (98.4) |
DASH diet non-adherence | 11,782 (99.2) | 2352 (99.5) | 48,005 (90.9) | 4231 (94.7) | ^ | ^ | ^ | ^ |
Healthy eating diet non-adherence | ^ | ^ | ^ | ^ | 284,124 (89.5) | 27,509 (91.4) | 4113 (89.9) | 1996 (90.4) |
Alcohol ≥1 drink/week | 5843 (49.2) | 1268 (53.6) | 37,721 (71.5) | 3604 (80.6) | 222,701 (70.2) | 23,895 (79.4) | 3802 (83.1) | 1916 (86.8) |
On diuretic therapy | 1203 (10.1) | 632 (26.7) | 3098 (5.9) | 886 (19.8) | 22,024 (6.9) | 6699 (22.2) | 761 (16.6) | 352 (15.9) |
Age ≥50 years | 6884 (57.9) | 1643 (69.5) | 40,199 (76.2) | 3581 (80.1) | 245,507 (77.3) | 24,336 (80.8) | 4256 (93.0) | 1874 (84.9) |
Age, mean (SD) | 51.4 (14.9) | 54.5 (12.4) | 56.4 (8.1) | 57.5 (8.0) | 56.7 (8.0) | 57.7 (7.9) | 60.8 (6.4) | 58.3 (7.5) |
Not treated with urate-lowering therapy | ^ | ^ | ^ | ^ | ^ | ^ | 455 (9.9) | 1461 (66.2) |