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Table 3 Transcripts validated in adalimumab good-responders by real-time quantitative polymerase chain reaction (RT-QPCR)

From: Transcriptome-wide study of TNF-inhibitor therapy in rheumatoid arthritis reveals early signature of successful treatment

Rank Target name Gene Rq Rq min Rq max Adjusted p value
1 Hs00190574_m1 LIN7A 0.69 0.59 0.8 0.01
2 Hs00191719_m1 CREB5 0.62 0.51 0.76 0.014
3 Hs00969559_m1 ENTPD1 0.79 0.71 0.88 0.019
4 Hs01565750_m1 ITGB7 1.51 1.25 1.82 0.02
5 Hs00185435_m1 HLA-DMA 1.34 1.17 1.52 0.023
6 Hs01075666_m1 IL6R 0.76 0.67 0.87 0.023
7 Hs01062258_m1 SLC8A1 0.68 0.59 0.79 0.025
8 Hs01555410_m1 IL1B 0.65 0.52 0.82 0.027
9 Hs00157950_m1 HLA-DOB 1.98 1.5 2.61 0.03
10 Hs01090216_m1 MGAM 0.56 0.41 0.76 0.03
11 Hs01072219_m1 TRAF5 1.47 1.27 1.69 0.031
12 Hs00171280_m1 AES 1.4 1.24 1.59 0.032
13 Hs00231092_m1 E2F5 1.61 1.26 2.07 0.035
14 Hs00207105_m1 ZFYVE16 0.8 0.71 0.9 0.037
15 Hs01109372_g1 HLA-DOA 1.63 1.3 2.03 0.037
16 Hs00152972_m1 TLR8 0.68 0.55 0.83 0.041
17 Hs00201585_m1 STAP1 1.51 1.22 1.86 0.042
  1. The relative quantification (Rq) values are equivalent to linear fold changes for each transcript defined as the inverse log2 of the change in relative cycle threshold (∆∆Crt) values between pre-treatment and 3 months. Minimum and maximum RQ values and p value are presented for each transcript along with p values adjusted for multiple tests. Transcripts with an Rq value below 1 exhibited reduced expression at 3 months compared to pre-treatment. Transcripts with an Rq value above 1 exhibited increased expression at 3 months compared to pre-treatment