Table 3 Characteristics and FDG PET/CT scan findings in SSc patients without ILD (n = 14) and with ILD (n = 22)
SSc patients without ILD (n = 14) | SSc patients with ILD (n = 22) | p value | |
|---|---|---|---|
Potential confusion factors | |||
Sex, female, no. (%) | 11 (78.6) | 9 (40.9) | 0.027 |
Age, years, mean ± SD | 54.6 ± 14.3 | 61.3 ± 10.6 | 0.12 |
BMI, kg/m2, mean ± SD | 25.6 ± 5.8 | 25.1 ± 6.0 | 0.80 |
Glycemia, g/L, mean ± SD | 1.1 ± 0.3 | 1.0 ± 0.1 | 0.35 |
Injection-perfusion duration, minutes, mean ± SD | 70.3 ± 11.9 | 75.6 ± 11.9 | 0.20 |
Disease characteristics | |||
Cutaneous subset, limited, no. (%) | 8 (57.1) | 11 (50.0) | 0.68 |
Disease duration, no. (%) | 0.11 | ||
< 2 years | 8 (57.1) | 6 (27.3) | |
2–4 years | 1 (7.1) | 7 (31.8) | |
> 4 years | 5 (35.7) | 9 (40.9) | |
Antibody status, no. (%) | |||
Anti-nuclear | 13 (92.9) | 21 (95.5) | NA |
Anti-centromere | 7 (50.0) | 5 (22.7) | 0.15 |
Anti-topoisomerase I | 1 (7.1) | 9 (40.9) | 0.054 |
Anti-RNA polymerase III | 1 (7.1) | 3 (13.6) | NA |
Organ involvement, no. (%) | |||
Lung | |||
Current %FVC, mean ± SD | 100 ± 10 | 80 ± 20 | 0.015 |
Current %DLCO, mean ± SD | 70 ± 20 | 50 ± 20 | 0.002 |
Osteoarticular | 7 (58.3) | 7 (35.0) | 0.20 |
Muscle | 3 (27.3) | 3 (23.1) | NA |
Current mRSS, mean ± SD | 13.6 ± 13.1 | 13.9 ± 11.5 | 0.96 |
Gastrointestinal tract | 9 (64.3) | 15 (68.2) | 1.00 |
Pulmonary hypertension | 3 (21.4) | 5 (22.7) | NA |
Calcinosis | 2 (14.3) | 2 (10.5) | NA |
Telangiectasia | 11 (78.6) | 11 (52.4) | 0.12 |
Ulcer digital | 3 (21.4) | 7 (35.0) | 0.47 |
Heart | 1 (7.1) | 5 (22.7) | NA |
Current treatments, no. (%) | |||
Steroids | 3 (21.4) | 10 (45.5) | 0.14 |
Immunosuppressive drugs | 3 (21.4) | 10 (45.5) | 0.14 |
18F-FDG PET/CT scan findings, no (%) | |||
Lung | |||
Abnormal interstitial pattern | 1 (7.1) | 14 (63.6) | <.001‡ |
hv/SUVmax, mean ± SD | 1.4 ± 0.8 | 2.6 ± 0.9 | <.001† |
s/SUVmax, mean ± SD | 9.8 ± 4.1 | 17.3 ± 6.0 | <.001† |
s/Intensities, median (IQR) | 0.0 (0.0; 0.0) | 8.0 (2.0; 12.0) | <.001† |
Lymph node | |||
Mediastinal, abnormal pattern | 2 (14.3) | 7 (31.8) | 0.43 |
Hilar, abnormal pattern | 2 (14.3) | 6 (27.3) | 0.44 |
Osteoarticular, abnormal pattern | 0 (0.0) | 1 (4.5) | NA |
Muscle, abnormal pattern | 1 (7.1) | 2 (9.1) | NA |
Skin, abnormal pattern | 1 (7.1) | 1 (4.5) | NA |
Esophagus, abnormal pattern | 9 (64.3) | 17 (77.3) | 1.0 |