Table 1 Multiplex analysis of cytokines, chemokines, and growth factors in serum
Analyte | 12 Week | 24 Week | 40 Week | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Chow, n = 6 | HF, n = 6 | Western, n = 6 | p value | Chow, n = 5 | HF, n = 6 | Western, n = 6 | p value | Chow, n = 5 | HF, n = 6 | Western, n = 6 | p value | |
Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | ||||
IL-1B | 13.9 (17.5) | 32.3 (58.6) | 39.4 (43.8) | 0.54 | 22.5 (26.9) | 15.3 (15.7) | 41.1 (89.3) | 0.72 | 2.0 (1.8) | 2.0 (1.4) | 6.4 (6.7) | 0.16 |
IL-6 | 17.2 (14.3) | 20.9 (28.1) | 47.6 (67.0) | 0.43 | 25.7 (31.9) | 28.7 (35.0) | 13.6 (12.2) | 0.63 | 2.7 (3.8) | 4.1 (1.9) | 20.0 (30.2) | 0.24 |
IL-10 | 45.8 (51.4) | 56.6 (85.1) | 153 (261.2) | 0.47 | 19.0 (24.1) | 17.2 (18.7) | 15.1 (18.7) | 0.95 | 0.5 (1.0) | 0.4 (0.9) | 2.1 (2.9) | 0.25 |
IP-10 | 129.4 (53.8) | 122.0 (32.4) | 139.5 (38.7) | 0.78 | 90.9 (53.2) | 105.9 (43.8) | 63.6 (49.5) | 0.34 | 106 (14.3) | 113.7 (24.2) | 144.7 (67.9) | 0.32 |
KC | 453.4 (323.3) | 690.2 (843.0) | 856.0 (1324) | 0.75 | 527.2 (363.1) | 452.0 (230.1) | 240.7 (108.5) | 0.17 | 191.1 (85.0) | 355.3 (223.4) | 258.8 (139.5) | 0.28 |
MCP-1 | 53.7 (58.7) | 51.6 (46.4) | 78.3 (65.6) | 0.68 | 54.3 (23.8) | 68.1 (42.3) | 165.2 (259.5) | 0.45 | 13.6 (9.6) | 63.8 (39.1) | 135.3 (93.7) *# | 0.02* |
TNFa | 28.4 (31.4) | 37.8 (54.2) | 41.9 (35.0) | 0.85 | 23.9 (23.6) | 16.0 (22.7) | 53.4 (96.2) | 0.54 | 1.0 (1.9) | 2.2 (4.1) | 3.0 (5.1) | 0.63 |
VEGF | 2.2 (1.87) | 6.8 (14.2) | 13.1 (27.8) | 0.59 | 2.9 (4.2) | 1.5 (2.5) | 1.9 (2.1) | 0.73 | 5.4 (8.4) | 2.1 (3.1) | 1.0 (0.5) | 0.33 |