Skip to main content

Table 1 Multiplex analysis of cytokines, chemokines, and growth factors in serum

From: Diet-induced obesity leads to behavioral indicators of pain preceding structural joint damage in wild-type mice

Analyte 12 Week 24 Week 40 Week
Chow, n = 6 HF, n = 6 Western, n = 6 p value Chow, n = 5 HF, n = 6 Western, n = 6 p value Chow, n = 5 HF, n = 6 Western, n = 6 p value
Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD)
IL-1B 13.9 (17.5) 32.3 (58.6) 39.4 (43.8) 0.54 22.5 (26.9) 15.3 (15.7) 41.1 (89.3) 0.72 2.0 (1.8) 2.0 (1.4) 6.4 (6.7) 0.16
IL-6 17.2 (14.3) 20.9 (28.1) 47.6 (67.0) 0.43 25.7 (31.9) 28.7 (35.0) 13.6 (12.2) 0.63 2.7 (3.8) 4.1 (1.9) 20.0 (30.2) 0.24
IL-10 45.8 (51.4) 56.6 (85.1) 153 (261.2) 0.47 19.0 (24.1) 17.2 (18.7) 15.1 (18.7) 0.95 0.5 (1.0) 0.4 (0.9) 2.1 (2.9) 0.25
IP-10 129.4 (53.8) 122.0 (32.4) 139.5 (38.7) 0.78 90.9 (53.2) 105.9 (43.8) 63.6 (49.5) 0.34 106 (14.3) 113.7 (24.2) 144.7 (67.9) 0.32
KC 453.4 (323.3) 690.2 (843.0) 856.0 (1324) 0.75 527.2 (363.1) 452.0 (230.1) 240.7 (108.5) 0.17 191.1 (85.0) 355.3 (223.4) 258.8 (139.5) 0.28
MCP-1 53.7 (58.7) 51.6 (46.4) 78.3 (65.6) 0.68 54.3 (23.8) 68.1 (42.3) 165.2 (259.5) 0.45 13.6 (9.6) 63.8 (39.1) 135.3 (93.7) *# 0.02*
TNFa 28.4 (31.4) 37.8 (54.2) 41.9 (35.0) 0.85 23.9 (23.6) 16.0 (22.7) 53.4 (96.2) 0.54 1.0 (1.9) 2.2 (4.1) 3.0 (5.1) 0.63
VEGF 2.2 (1.87) 6.8 (14.2) 13.1 (27.8) 0.59 2.9 (4.2) 1.5 (2.5) 1.9 (2.1) 0.73 5.4 (8.4) 2.1 (3.1) 1.0 (0.5) 0.33
  1. Values are displayed in pg/mL and analyzed by one-way ANOVA. P < 0.05 is significant
  2. *Significantly different from chow diet by Tukey's post hoc test
  3. #Significantly different from HF diet by Tukey’s post hoc test