Impact of disease activity on impaired glucose metabolism in patients with rheumatoid arthritis

Table 3 Magnitude of the contribution of markers of inflammation and disease activity parameters in the HOMA2 indices in the rheumatoid arthritis group

	logHOMA2-IR R²	logHOMA2-%S R²	logC-peptide R²
Base model
Age, hypertension, BMI, TGL	0.264	0.285	0.201
Base model + inflammation markers
ESR	0.270	0.293	0.250
CRP	0.273	0.300	0.209
IL-6	0.266	0.292	0.196
Base model + RA activity parameters
MMP3	0.299	0.330	0.199
DAS28-ESR	0.315	0.336	0.235
DAS28-CRP	0.321	0.342	0.219
DAS28-ESR ≥ 5.1	0.355	0.374	0.249
HAQ	0.308	0.332	0.208
VAS	0.325	0.343	0.217
TJC	0.332	0.351	0.211
SJC	0.280	0.300	0.202

Abbreviations: R² coefficient of determination, BMI body mass index, CRP C-reactive protein, DAS28 disease activity score of 28 joints, ESR erythrocyte sedimentation rate, HAQ Health Assessment Questionnaire, HOMA2-IR Homeostasis Model Assessment of insulin resistance, HOMA2-%S Homeostasis Model Assessment of insulin sensitivity, IL interleukin, IR insulin resistance, MMP3 matrix metalloproteinase-3, RA rheumatoid arthritis, SJC number of swollen joints, TGL triglycerides, TJC number of tender joints, VAS visual analogue scale (0–100 mm)

ISSN: 1478-6362