Fig. 1
From: Periostin loss-of-function protects mice from post-traumatic and age-related osteoarthritis
Postn−/− mice lack Postn protein. a Primers used for mouse genotyping. b Diagram of targetting vector for genertaion of Postn−/− mice. c Genotyping analysis of wt, Postn−/− and Postn+/− mice. d Immunostaining of Postn in the knee joint revealed that wt (n = 3) mice expressed periostin (red arrows) whereas Postn−/− (n = 3) mice showed no staining for Postn (left panel: 10x, right panel 20x). Scale bar = 100 μm. e Serum Postn levels were negligible and significantly low in Postn−/− (n = 6) than wt mice (n = 11) (Mann-Whitney test)