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Table 1 Comparison of demographic characteristics of IgG4-RD with and without hypocomplementemia at baseline

From: Clinical characteristics and outcome of IgG4-related disease with hypocomplementemia: a prospective cohort study

Characteristics at baseline Hypocomplementemia Group(n = 65) Normal Complement Group(n = 244) P- value
Demographic features
 Gender (male), n (%) 47 (72.3%) 144 (59.0%) 0.05
 Age of diagnosis, mean ± SD 55.85 ± 10.89 53.05 ± 13.00 0.113
 Duration of disease (medium months, IQR) 12 (4, 36) 12 (6, 48) 0.131
 Allergy history (n, %) 40 (61.5%) 125 (51.2%) 0.139
 Number of organs involved (mean ± SD) 4.88 ± 1.79 2.89 ± 1.36 < 0.001***
 IgG4-RD RI, mean ± SD 15.74 ± 5.78 9.64 ± 4.33 < 0.001***
Organ involvement (n%)
 Lymph node 43 (66.2%) 88 (36.1%) < 0.001***
 Lacrimal gland 43 (66.2%) 111 (45.5%) 0.003**
 Submandibular gland 41 (63.1%) 101 (41.4%) 0.001**
 Pancreas 33 (50.8%) 66 (27.1%) < 0.001***
 Lung 33 (50.8%) 44 (18.0%) < 0.001***
 Paranasal sinus 27 (41.5%) 68 (27.9%) 0.029*
 Parotid gland 22 (33.8%) 28 (11.5%) < 0.001***
 Bile duct 20 (30.8%) 35 (14.3%) 0.002**
 Kidney 12 (18.5%) 26 (10.7%) 0.082
 Prostate gland 10 (15.4%) 10 (4.1%) 0.0218*
 Retroperitoneum 8 (12.3%) 46 (18.9%) 0.229
 Aorta/artery 5 (7.7%) 28 (11.5%) 0.442
 Pituitary 3 (4.6%) 7 (2.9%) 0.443
 Gastrointestinal tract 0 (0.0%) 4 (1.6%)  
 Mediastinum 3 (4.6%) 6 (2.5%) 0.349
 Thyroid (Riedel’s) 3 (4.6%) 10 (4.1%) 0.835
Serological features
 C3(normal 0.73–1.46 g/L) 0.54 ± 0.17 0.99 ± 0.33 < 0.001***
 C4(normal 0.10–0.40 g/L) 0.061 ± 0.047 0.19 (0.14,0.25) < 0.001***
 WBC(109/L) 6.67 ± 1.84 6.54 (5.58, 7.75) 0.894
 HGB(g/L) 132.35 ± 18.38 134.37 ± 22.07 0.508
 PLT(109/L) 215.80 ± 59.00 240.30 ± 75.80 0.017*
 EOS(109/L) 0.39 (0.14,0.69) 0.19 (0.10,0.33) 0.001**
 ESR (mm/H) 46.34 ± 32.40 16 (7, 37) < 0.001***
 hsCRP (mg/L) (normal<  8mg/L) 2.5 1(0.82, 8.64) 1.86 (0.64, 5.68) 0.117
 IgG (normal 7.0–17.0 g/L) 30.92 ± 15.31 18.05 ± 8.79 < 0.001***
 IgA (normal 0.7–4.0 g/L) 1.59 ± 0.78 2.36 ± 1.32 < 0.001***
 IgM (normal 0.4–2.3 g/L) 0.87 ± 0.63 0.81 (0.54, 1.23) 0.132
 IgE (KU/L)(normal<60KU/L) 471.0 (246.75, 880.00) 222.00 (63.70, 609.00) < 0.001***
 IgG1(normal 490–1140 mg/dL) 1295.11 ± 539.48 907.73 ± 439.79 < 0.001***
 IgG2(normal 150–640 mg/dL) 666.83 ± 542.76 612.56 ± 256.77 0.259
 IgG3(normal 20–110 mg/dL) 100.56 ± 80.81 50.54 ± 41.23 < 0.001***
 IgG4(normal 80–135 mg/dL) 2614.13 ± 1915.39 547.50 (274.23,1215.50) < 0.001***
 IgG4/IgG 0.80 ± 0.44 0.44 ± 0.34 < 0.001***
 RF positive (n, %) 20 (n = 57, 35.1%) 44 (n = 166, 26.5%) 0.217
  1. IG4-RD RI IgG4-RD responder index, WBC white blood cell count, HGB hemoglobin, PLT platelet count, EOS eosinophil count, ESR estimated sedimentation rate, hsCRP hypersensitive C-reactive protein, Ig immunoglobulin, RF-positive the level of rheumatoid factor ≥ 20 IU/ml
  2. *P < 0.05, **P < 0.01, ***P < 0.001