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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Upregulated endonuclease Regnase-1 suppresses osteoarthritis by forming a negative feedback loop of catabolic signaling in chondrocytes

Fig. 1

Regnase-1 is upregulated in chondrocytes by OA-associated catabolic factors. a Heat map of RNase mRNA expression levels obtained by microarray analysis of primary-culture mouse articular chondrocytes treated with IL-1β, Ad-HIF-2α, or Ad-ZIP8 (n = 4). b Relative mRNA levels of ZC3H12 family members in unstimulated chondrocytes (n = 5). c–e Relative mRNA levels of Regnase-1 and the indicated molecules in chondrocytes stimulated with IL-1β (c), infected with Ad-HIF-2α (d), or infected with Ad-ZIP8 (e) (n = 5). f Representative Western blot images of Regnase-1 in chondrocytes treated with Ad-Regnase-1 or IL-1β (n = 4). Lamin B was used as a loading control. Values in b–e are means ± s.e.m. and one-way ANOVA with Bonferroni’s post hoc test (*p < 0.05, **p < 0.005, ***p < 0.0005)

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Arthritis Research & Therapy

ISSN: 1478-6362

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