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Fig. 7 | Arthritis Research & Therapy

Fig. 7

From: Upregulated endonuclease Regnase-1 suppresses osteoarthritis by forming a negative feedback loop of catabolic signaling in chondrocytes

Fig. 7

SAA3 does not modulate OA pathogenesis. a, b Immunohistochemical staining (a) and Safranin-O staining (b) images from WT mice IA-injected with Ad-C or Ad-SAA3 (n = 10 mice per group). Mice were sacrificed at 3 weeks post-injection. c Representative RT-PCR images of the indicated molecules in chondrocytes infected with Ad-C or Ad-SAA3 for 36 h (n = 6). d, e Sham- or DMM-operated WT mice were IA-injected with Ad-C or Ad-SAA3. Representative Safranin-O staining images (d) and scoring of OARSI grade, osteophyte size, and SBP thickness (e) at 6 weeks after the operation (n = 10 mice per group). Means ±95% CI with Mann-Whitney U test for OARSI grade and means ± s.e.m. with two-tailed t test for osteophyte size and SBP thickness. ns, not significant. Scale bar: 50 μm

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Arthritis Research & Therapy

ISSN: 1478-6362

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